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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Early Human Developm...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Early Human Development
Article . 1996 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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To what extent does a given heart rate correlate with following heart rates in the developing human fetus?

Authors: M, Ogawa; T, Yoshizato; T, Takashima; T, Koyanagi; T, Suzuki; H, Nakano;

To what extent does a given heart rate correlate with following heart rates in the developing human fetus?

Abstract

Abstract To quantitatively determine the extent to which a given heart rate correlates with the following heart rate(s) at any gestational age, we studied 181 uncomplicated human fetuses between 23 and 41 weeks gestation. A continuous 90–120 min observation was made for each case using external Doppler-ultrasound cardiotocography. For every individual fetal heart rate dataset, ‘probability distribution matrices' were calculated with fetal heart rates (termed FHRs) at 1-beat/min (bpm) intervals, and the beat-to-beat(s) difference (termed DFHR n : 1 ≤ n ≤ 1000), also at 1-bpm intervals arranged in rows and columns, respectively, with probability in each element. Using ‘piecewise linear regression', (1) the difference between the DFHR 1 ( n = 1) probability distribution matrix as the ‘control' and a given DFHR n ( n ≥ 2) probability matrix as the ‘variable', was analyzed to obtain the statistically critical point(s) (termed ‘beat-delay' in beats) for each fetus, and (2) a scattergram of ‘beat-delay' vs. gestational age-group, made from all fetuses studied, was analyzed to reveal any critical age(s) in gestation. One statistically significant point was evident at 28–29 weeks gestation. During the period prior to the critical point, a linear decrement in ‘beat-delay' with 21 beats (mean) at 23–25 weeks to 11 beats at 28–29 weeks gestation was noted, suggesting that the conduction system-oriented heart beat gradually comes under functional control of the autonomic nervous system as well as under possible regulation by the maturating medulla oblongata. From the critical point, through to term, there was no significant change in ‘beat-delay' ranging from 7–11 beats, thereby implying that the fetal heart rate becomes stabilized as a result of the control rendered by the more developed autonomic nervous system function. Whether or not brain function cephalad to the medulla oblongata actually participates in this phenomenon remains to be elucidated.

Related Organizations
Subjects by Vocabulary

Microsoft Academic Graph classification: medicine.medical_specialty Fetus medicine.diagnostic_test business.industry Gestational age Autonomic nervous system Endocrinology Internal medicine Heart rate medicine Medulla oblongata Gestation Heart rate variability Cardiotocography business

Keywords

Obstetrics and Gynecology, Gestational Age, Heart Rate, Fetal, Embryonic and Fetal Development, Pregnancy, Pediatrics, Perinatology and Child Health, Linear Models, Humans, Female, Probability

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    2
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
bronze