publication . Article . 2021

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture

Mehmet Murat Bala; Abdullah Alper Şahin; Mehmet Akif Boz; Yasin Durukan; Tulin Firat; M. Pakdil; Kutay Engin Ozturan;
Open Access
  • Published: 01 Sep 2021 Journal: Medical Science Monitor, volume 27 (eissn: 1643-3750, Copyright policy)
  • Publisher: International Scientific Information, Inc.
Abstract
BACKGROUND In this study, we aimed to investigate the effects of N-butyl-2-cyanoacrylate (cyanoacrylate) on the biomechanical and histopathological aspects of tendon healing in a rabbit model of Achilles tendon injury. MATERIAL AND METHODS In total, 36 rabbits were randomized to experimental (cyanoacrylate) and control groups (n=36 tendons in each group). A simple suture was used in the control group and a simple suture plus cyanoacrylate was used in the experimental group. Nine rabbits from each group were euthanized at week 4 and week 6 after surgery for histopathological and biomechanical testing. RESULTS Granulation tissue formation was significantly greater in the experimental group in week 4 and week 6 than in the control group. Foreign body giant cell formation was significantly higher in the experimental group in week 4 and week 6. The maximum rupture force was significantly higher in the experimental group in week 4 and week 6 than in the control group. Elasticity and stiffness were comparable between groups in week 4; however, stiffness, but not elasticity, was significantly higher in the experimental group in week 6. CONCLUSIONS In the short term, cyanoacrylate enhanced tendon endurance in both a histopathological and biomechanical manner. We conclude that the early initiation of rehabilitation in patients may be safe in cases of cyanoacrylate use for surgical repair of tendon injury.
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free text keywords: Clinical Research, Cyanoacrylates, Rabbits, Tendon Injuries, General Medicine, Suture (anatomy), Tendon healing, Cyanoacrylate, law.invention, law, Granulation tissue, medicine.anatomical_structure, medicine, business.industry, business, Tendon, Early initiation, Surgery, medicine.medical_specialty, Achilles tendon rupture, medicine.symptom, In patient
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