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Phosphoproteomic Analysis and Protein-Protein Interaction of Rat Aorta GJA1 and Rat Heart FKBP1A after Secoiridoid Consumption from Virgin Olive Oil: A Functional Proteomic Approach

Authors: Pedret A; Catalán Ú; Rubió L; Baiges I; Herrero P; Piñol C; Rodríguez-Calvo R; +4 Authors

Phosphoproteomic Analysis and Protein-Protein Interaction of Rat Aorta GJA1 and Rat Heart FKBP1A after Secoiridoid Consumption from Virgin Olive Oil: A Functional Proteomic Approach

Abstract

© 2020 American Chemical Society. All rights reserved. Protein functional interactions could explain the biological response of secoiridoids (SECs), main phenolic compounds in virgin olive oil (VOO). The aim was to assess protein-protein interactions (PPIs) of the aorta gap junction alpha-1 (GJA1) and the heart peptidyl-prolyl cis-trans isomerase (FKBP1A), plus the phosphorylated heart proteome, to describe new molecular pathways in the cardiovascular system in rats using nanoliquid chromatography coupled with mass spectrometry. PPIs modified by SECs and associated with GJA1 in aorta rat tissue were calpain, TUBA1A, and HSPB1. Those associated with FKBP1A in rat heart tissue included SUCLG1, HSPE1, and TNNI3. In the heart, SECs modulated the phosphoproteome through the main canonical pathways PI3K/mTOR signaling (AKT1S1 and GAB2) and gap junction signaling (GAB2 and GJA1). PPIs associated with GJA1 and with FKBP1A, the phosphorylation of GAB2, and the dephosphorylation of GJA1 and AKT1S1 in rat tissues are promising protein targets promoting cardiovascular protection to explain the health benefits of VOO.

Country
Spain
Related Organizations
Keywords

Medicina ii, Biotecnología, Proteome, Protein-protein interactions, Planejamento urbano e regional / demografia, Ciências agrárias i, Odontología, Nutrição, Medicina i, Food science & technology, Agriculture, multidisciplinary, Agricultural and Biological Sciences (Miscellaneous),Agriculture,Agriculture, Multidisciplinary,Chemistry (Miscellaneous),Chemistry, Applied,Food Science & Technology, General chemistry, Ciências biológicas iii, Agricultural and biological sciences (miscellaneous), Ciências ambientais, Zootecnia / recursos pesqueiros, Medicina veterinaria, Engenharias iii, Engenharias ii, Chemistry (all), Biodiversidade, Astronomia / física, Secoiridoids, Interdisciplinar, Agriculture, Química, Engenharias iv, Chemistry, applied, General medicine, Farmacia, Agricultural and biological sciences (all), Saúde coletiva, Ensino, Tissues, Educação, Chemistry (miscellaneous), Phosphoproteome, Ciência de alimentos, General agricultural and biological sciences, Materiais, Ciências biológicas ii, Ciências biológicas i, Ciência da computação

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  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    impulse
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    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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