Powered by OpenAIRE graph
Found an issue? Give us feedback

CNR

National Research Council
Country: Italy
Funder
Top 100 values are shown in the filters
Results number
arrow_drop_down
1,799 Projects, page 1 of 360
  • Funder: EC Project Code: 101066678
    Funder Contribution: 172,750 EUR

    Cardiometabolic traits and risk factors including cardiovascular diseases, type 2 diabetes, and hypertension are the leading causes of death worldwide. These conditions exhibit some degree of sex differences, including differences in incidence or prevalence, age of onset, severity, disease progression, susceptibility, response to treatment and pharmacological adverse events. Unfortunately, the reasons behind this sex dimorphism are largely unknown, hampering the realization of an effective personalized medicine. My project will focus on understanding the genetic and molecular components that differentially impact men and women. I will first carry out sex stratified genome-wide association studies for cardiovascular diseases, type 2 diabetes, hypertension and obesity using large population biobanks to evaluate the effects of known-genetic variants within each sex and to identify novel loci that may have been previously undetected. I will then use molecular quantitative trait loci (QTLs) to identify specific gene expression changes and proteins modulated by these variants and that are likely to be involved in sex-specific development of cardiometabolic traits and modulation of risk factors. I will then validate putative causal genes using Mendelian randomization approaches. This will lead to optimize therapeutics and find new drug target to perform equally well in males and females and will open the door to improve personalized and precision medicine in the near future.

    more_vert
  • Funder: EC Project Code: 235386
    more_vert
  • Funder: EC Project Code: 276574
    more_vert
  • Funder: EC Project Code: 101062863
    Funder Contribution: 172,750 EUR

    We are in an era of demand for new, high-performance and sustainable plastics. The challenge is to counterbalance the actual need of society for disposable devices without compromising the sustainability of the overall production. Within the polymer field, polyolefins account for more than 50% of global plastics demand. However, their main drawback is represented by their hydrophobicity and their poor applicability in blending, adhesion and dyeing due to a lack of functional groups. In this regard, one fundamental challenge is to develop a new strategy that combines polymer synthesis and the incorporation of polar moieties into polyolefins. Within this context, POLYFUN seeks to deliver functional polyolefins by employing a single iron-based catalyst to perform two subsequent catalytic steps in a one-pot strategy. This approach, although being an important tool at the molecular level, has not yet found any application in the polymer field to access materials with intriguing and robust properties in one single process. From a scientific and technological perspective, POLYFUN intends to fabricate functionalized polymers with tunable and unique properties with an innovative approach in the field. This project is highly interdisciplinary, involving different research areas such as organic chemistry, catalysis, and material science. As such, it is envisioned that the development of this new strategy can generate breakthrough scientific papers, valuable discoveries and/or potential patents. This fellowship brings a two-fold transfer of knowledge: advanced techniques in organic chemistry to the host institution and material chemistry to the fellow. Overall, the project’s multidisciplinarity and intersectoral nature will broaden the fellow’s competencies and will place her in a competitive position for her next career move.

    more_vert
  • Funder: EC Project Code: 664782
    Overall Budget: 150,000 EURFunder Contribution: 150,000 EUR

    Tissue and organ failure, caused by injury or other type of damage, accounts for a large part of the health care costs in EU and U.S. Current surgical or grafting procedures are only partly successful in restoring the functions of the damaged tissues.Tissue Engineering has emerged as a rapidly expanding field for repair and regeneration of damaged tissue and organs.This involves the seeding and attachment of human cells onto a scaffold through in-vitro, or a combination of in-vitro and in-vivo. Existing scaffold fabrication techniques are time consuming and costly. We plan to take the first steps towards the commercialization of a novel system to fabricate tissue scaffolds made of Graphene Oxide (GO) in an extremely dynamical and efficient manner. The prototype consists of opto-mechanical and laser components that will be used to dynamically deform the initially flat surface consisting of a single layer of GO deposited over a porous membrane. Specifically, we will utilize a Spatial Light Modulator laser and a novel software application in order to realize a pixelated surface with the desired profile. The spatial deformation will be controlled and detected with the use of Atomic Force Microscopy. Special shapes of the asperities, i.e. local surface maxima of a rough surface, enhance adhesion over the entire surface when in contact with a biological material. Analogously to known natural surfaces with hierarchical roughness, we aim to mimic this kind of effects by using Graphene thanks to its high strength and flexibility. All in all, the goal of VANGuaRD is two-fold: (1) to establish the technical feasibility of our idea by designing and building a highly versatile prototype device that includes both hardware and software components for fabricating easily reconfigurable GO-based scaffolds using only a single substrate. (2) to establish the commercialization potential of such system by means of designing a viable and scalable business model.

    more_vert
Powered by OpenAIRE graph
Found an issue? Give us feedback

Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.

Content report
No reports available
Funder report
No option selected
arrow_drop_down

Do you wish to download a CSV file? Note that this process may take a while.

There was an error in csv downloading. Please try again later.