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assignment_turned_in Project2022 - 2023Partners:NTUNTUFunder: UKRI Project Code: EP/X52668X/1Funder Contribution: 973,396 GBPAbstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
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For further information contact us at helpdesk@openaire.euassignment_turned_in Project2022 - 2026Partners:NTUNTUFunder: UKRI Project Code: 2747241The EPSRC and SFI in Sustainable Chemistry - Atoms to Products (A2P) CDT is a four-year programme that provides advanced training and education to students, to prepare for rewarding careers in academia, industry and related sectors. The first-year training framework involves Core training attended by all students and Theme-specific training activities, where the students work as teams in one of four contemporary research themes (which are likely to change each year), supervised by several academic staff and industry scientists. During the first year, the students will select and develop their research projects and the details of the project will be fully known by the end of the year 1. CDT Research Theme: H2P - Heat to Power
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For further information contact us at helpdesk@openaire.euassignment_turned_in Project2009 - 2012Partners:NTUNTUFunder: UKRI Project Code: G0801271Funder Contribution: 439,070 GBPThe muscle of the tiny worm I use in my studies (C. elegans) is a surprisingly good model for muscles in human beings. It can be studied more easily and in many experimental situations that are impossible in people. At the moment, we do not understand what causes muscle wasting in people, a problem that affects the elderly and those with spinal injuries among others. My previous worm studies may offer some clues, others are applying my results to studies in human beings. Muscle wasting occurs in response to spaceflight and immobilization. I discovered that in worms, a special complex of proteins (known as ?dense bodies? and which attach worm muscle to skeleton) were decreased after spaceflight. My experiments on Earth show that reducing these proteins causes muscle tissue breakdown. Others at my University found that a protein in human focal adhesions is decreased following cast immobilization. Additionally, mutations in focal adhesions cause Limb Girdle Muscular Dystrophies. The same proteins are found in worm dense bodies and human focal adhesions. Thus, similar changes are observed in worm and human attachment complexes and these changes cause worm muscle wasting. We currently have no idea what the controlling and mediating factor are, if these factors also regulate human muscle wasting, nor if they differ among various clinical populations displaying wasting (e.g. trauma patients, burn patients, bed ridden patients, the elderly). I want to answer these questions. I currently want to understand one mechanism regulating wasting in worms. The ultimate goal is understanding all of the mechanisms regulating wasting in human beings. I feel that once we do, we can understand the differences between patients and identify drug targets providing appropriate treatment(s) to each group of patients. It is my hope that by first gaining an understanding of the regulation and treatment of wasting in a simple organism, we can more rapidly and cost effectively demonstrate the existence and treatment of the same processes in people. I will also continue my efforts of communicating results directly to the public. In the past this has included making results freely available on-line, giving free talks to the public, actively engaging school children in my research, and communicating my work via reporters and radio and television presenters from around the world (in the UK these include the BBC, the Discovery Channel, CNN, and all of the ?wire? services that provide stories to newspapers).
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For further information contact us at helpdesk@openaire.euassignment_turned_in Project2020 - 2020Partners:NTUNTUFunder: UKRI Project Code: EP/V518372/1Funder Contribution: 66,666 GBPDoctoral Training Partnerships: a range of postgraduate training is funded by the Research Councils. For information on current funding routes, see the common terminology at https://www.ukri.org/apply-for-funding/how-we-fund-studentships/. Training grants may be to one organisation or to a consortia of research organisations. This portal will show the lead organisation only.
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For further information contact us at helpdesk@openaire.euassignment_turned_in Project2007 - 2013Partners:NTUNTUFunder: UKRI Project Code: G0601176Funder Contribution: 1,590,250 GBPThere are currently heightened public concerns over infection rates in UK hospitals, and in particular those caused by so called ?superbugs? that have become resistant to available antibiotics. One such bug is Clostridium difficile. It causes debilitating diarrhoea, which in extreme cases can kill. It mainly affects the elderly. As this proportion of the population is increasing, the disease is becoming more common. Worryingly, a new, even more deadly variant has now arrived in Europe from North America. Aside from the human suffering, it costs the NHS over #402 million per year, and now is responsible for more deaths per year than MRSA. To control infections, we need to understand how an organism causes disease. Under Wellcome Trust sponsorship, the complete genome sequence of the organism (ie., its genetic blueprint) has been determined. However, whilst we now know the sequences of every gene in the C. difficile chromosome, we do not understand what they are doing. The best way of working out what genes do, is to mutate them (make them non-functional) and assess the consequences. Until now this has not been possible. We have now developed the tools needed, and wish to use them to better understand how this bug causes disease. This should eventually lead to better ways of controlling the disease.
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For further information contact us at helpdesk@openaire.euvisibility 69visibility views 69 download downloads 21 Powered bymore_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=ukri________::787f80affc8fffd07d246f7aff3678a4&type=result"></script>'); --> </script>
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