search
The following results are related to Rural Digital Europe. Are you interested to view more results? Visit OpenAIRE - Explore.

  • Rural Digital Europe
  • CR
  • Environmental Health Perspectives

Relevance
arrow_drop_down
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Liliana A. Zúñiga-Venegas; Carly Hyland; María Teresa Muñoz-Quezada; Lesliam Quirós-Alcalá; +18 Authors

    BACKGROUND: Multiple epidemiological studies have shown that exposure to pesticides is associated with adverse health outcomes. However, the literature on pesticide-related health effects in the Latin American and the Caribbean (LAC) region, an area of intensive agricultural and residential pesticide use, is sparse. We conducted a scoping review to describe the current state of research on the health effects of pesticide exposure in LAC populations with the goal of identifying knowledge gaps and research capacity building needs. METHODS: We searched PubMed and SciELO for epidemiological studies on pesticide exposure and human health in LAC populations published between January 2007 and December 2021. We identified 233 publications from 16 countries that met our inclusion criteria and grouped them by health outcome (genotoxicity, neurobehavioral outcomes, placental outcomes and teratogenicity, cancer, thyroid function, reproductive outcomes, birth outcomes and child growth, and others). RESULTS: Most published studies were conducted in Brazil (37%, n = 88) and Mexico (20%, n = 46), were cross-sectional in design (72%, n = 167), and focused on farmworkers (45%, n = 105) or children (21%, n = 48). The most frequently studied health effects included genotoxicity (24%, n = 62) and neurobehavioral outcomes (21%, n = 54), and organophosphate (OP) pesticides were the most frequently examined (26%, n = 81). Forty-seven percent (n = 112) of the studies relied only on indirect pesticide exposure assessment methods. Exposure to OP pesticides, carbamates, or to multiple pesticide classes was consistently associated with markers of genotoxicity and adverse neurobehavioral outcomes, particularly among children and farmworkers. DISCUSSION: Our scoping review provides some evidence that exposure to pesticides may adversely impact the health of LAC populations, but methodological limitations and inconsistencies undermine the strength of the conclusions. It is critical to increase capacity building, integrate research initiatives, and conduct more rigorous epidemiological studies in the region to address these limitations, better inform public health surveillance systems, and maximize the impact of research on public policies. Fil: Cortés, Sandra. Pontificia Universidad Católica de Chile. Departamento de Salud Pública. Centro de Desarrollo Urbano Sustentable. Centro Avanzado de Enfermedades Crónicas (ACCDiS); Chile Fil: Muñoz-Quezada, María Teresa. Universidad Católica del Maule. Facultad de Ciencias de la Salud. Centro de Investigación en Neuropsicología y Neurociencias Cognitivas; Chile Fil: Lucero, Boris A. Universidad Católica del Maule. Facultad de Ciencias de la Salud. Centro de Investigación en Neuropsicología y Neurociencias Cognitivas; Chile Fil: de Joode, Berna van Wendel. Universidad Nacional. Central American Institute for Studies on Toxic Substances. Infants’ Environmental Health Study; Costa Rica Fil: Quirós-Alcalá, Lesliam. John Hopkins University. Bloomberg School of Public Health. Department of Environmental Health and Engineering; Estados Unidos Fil: Mora, Ana M. Universidad Nacional. Central American Institute for Studies on Toxic Substances. Infants’ Environmental Health Study; Costa Rica Fil: Quirós-Alcalá, Lesliam. University of Maryland. School of Public Health. Maryland Institute of Applied Environmental Health; Estados Unidos Fil: Cardenas, Andres. University of California. School of Public Health. Center for Environmental Research and Community Health; Estados Unidos Fil: Smith, Anna R. University of California. School of Public Health. Center for Environmental Research and Community Health; Estados Unidos Fil: Hyland, Carly. University of California. School of Public Health. Center for Environmental Research and Community Health; Estados Unidos Fil: Mora, Ana M. University of California. School of Public Health. Center for Environmental Research and Community Health; Estados Unidos Fil: Zúñiga-Venegas, Liliana A. Universidad Católica del Maule. Centro de Investigaciones de Estudios Avanzados del Maule; Chile Fil: Jara, Juan P. Gutiérrez. Universidad Católica del Maule. Centro de Investigaciones de Estudios Avanzados del Maule; Chile Fil: Foerster, Claudia. Universidad de O’Higgins. Instituto de Ciencias de la Agroalimentarias, Animales y Ambientales; Chile Fil: Ramírez-Santana, Muriel. Universidad Católica del Norte. Facultad de Medicina. Departamento de Salud Pública; Chile Fil: Buralli, Rafael. Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Saúde Ambiental; Brasil Fil: Gouveia, Nelson. Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Preventiva; Brasil Fil: Handal, Alexis J. University of Michigan School of Public Health. Department of Epidemiology; Estados Unidos Fil: Hyland, Carly. Boise State University. School of Public Health and Population Science; Estados Unidos Fil: Tirado, Noemi. Universidad Mayor de San Andrés. Facultad de Medicina. Instituto de Genética; Bolivia Fil: Fernandez, Ricardo A. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina Fil: Muñoz, María Pía. Universidad de Chile. Facultad de Medicina. Escuela de Salud Pública; Chile Fil: Butinof, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina Fil: Calaf, Gloria M. Universidad de Tarapacá. Instituto de Alta Investigación; Chile Fil: da Silva, Agnes Soares. Pan American Health Organization. Estados Unidos Fil: Calaf, Gloria M. Columbia University Medical Center; Estados Unidos

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Producción Académica...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Environmental Health Perspectives
    Article . 2022 . Peer-reviewed
    Data sources: Crossref
    addClaim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    2
    citations2
    popularityAverage
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    more_vert
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Producción Académica...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Environmental Health Perspectives
      Article . 2022 . Peer-reviewed
      Data sources: Crossref
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ana M. Mora; Leonel Córdoba; Juan Camilo Cano; David Hernández-Bonilla; +8 Authors

    Programa Infantes y Salud Ambiental Programa ISA Infant´s Environmental Health Study Infant´s Environmental Health Program BACKGROUND: Although growing evidence suggests that early-life excess manganese (Mn) impairs neurodevelopment, data on the neurodevelopmental effects of mancozeb, a fungicide containing Mn, and its main metabolite ethylenethiourea (ETU) are limited. OBJECTIVE: We examined whether prenatal mancozeb exposure and excess Mn were associated with neurodevelopment in 355 1-y-old infants living near banana plantations with frequent aerial mancozeb spraying in Costa Rica. METHODS: We measured urinary ETU, hair Mn, and blood Mn concentrations in samples collected 1–3 times during pregnancy from mothers enrolled in the Infants’ Environmental Health (ISA) study. We then assessed neurodevelopment in their 1-y-old infants using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). We estimated exposure–outcome associations using linear regression models adjusted for maternal education, parity, gestational age at birth, child age, Home Observation for Measurement of the Environment score, and location of neurodevelopmental assessment. RESULTS: Median (P25–P75) urinary ETU, hair Mn, and blood Mn measured during pregnancy were 3:3 lg=L (2.4–4.9; specific gravity–corrected), 1:7 lg=g (0.9–4.1), and 24:0 lg=L (20.3–28.0), respectively. Among girls, higher ETU was associated with lower social-emotional scores [b per 10-fold increase= −7:4 points (95% CI: −15:2, 0.4)], whereas higher hair Mn was associated with lower cognitive scores [−3:0 (−6:1, 0.1)]. Among boys, higher hair Mn was associated with lower social-emotional scores [−4:6 (−8:5, −0:8)]. We observed null associations for blood Mn, language, and motor outcomes. CONCLUSIONS: Our findings indicate that maternal exposure to mancozeb and excess Mn during pregnancy may have adverse and sex-specific effects on infant neurodevelopment. ANTECEDENTES: Aunque la evidencia creciente sugiere que el exceso de manganeso (Mn) en las primeras etapas de la vida afecta el desarrollo neurológico, los datos sobre los efectos del desarrollo neurológico de mancozeb, un fungicida que contiene Mn, y su principal metabolito etilentiourea (ETU) son limitados. OBJETIVO: Examinamos si la exposición prenatal a mancozeb y el exceso de Mn estaban asociados con el desarrollo neurológico en 355 bebés de 1 año que vivían cerca de plantaciones de banano con fumigación aérea frecuente de mancozeb en Costa Rica. MÉTODOS: Medimos las concentraciones de ETU urinaria, Mn en el cabello y Mn en sangre en muestras recolectadas de 1 a 3 veces durante el embarazo de madres inscritas en el estudio Infants ’Environmental Health (ISA). Luego evaluamos el desarrollo neurológico en sus bebés de 1 año utilizando las Escalas de Bayley para bebés y niños pequeños Desarrollo, 3ª edición (BSID-III). Estimamos las asociaciones exposición-resultado utilizando modelos de regresión lineal ajustados por educación materna, paridad, edad gestacional al nacer, edad del niño, observación en el hogar para medir el puntaje ambiental y ubicación de la evaluación del desarrollo neurológico. RESULTADOS: La ETU urinaria mediana (P25-P75), el Mn del cabello y el Mn en sangre medidos durante el embarazo fueron 3: 3 lg = L (2.4-4.9; gravedad específica corregida), 1: 7 lg = g (0.9-4.1), y 24: 0 lg = L (20,3-28,0), respectivamente. Entre las niñas, una ETU más alta se asoció con puntuaciones socioemocionales más bajas [b por aumento de 10 veces = −7: 4 puntos (IC del 95%: −15: 2, 0,4)], mientras que una mayor Mn de cabello se asoció con puntuaciones cognitivas más bajas [−3: 0 (−6: 1, 0,1)]. Entre los niños, una mayor cantidad de cabello Mn se asoció con puntuaciones socioemocionales más bajas [−4: 6 (−8: 5, −0: 8)]. Observamos asociaciones nulas para Mn en sangre, lenguaje y resultados motores. CONCLUSIONES: Nuestros hallazgos indican que la exposición materna al mancozeb y el exceso de Mn durante el embarazo pueden tener efectos adversos y específicos del sexo en el desarrollo neurológico infantil. Universidad Nacional, Costa Rica Ministerio de Ciencia, Tecnología y Telecomunicaciones (MICITT), Costa Rica International Development Research Centre (IDRC), Canadá Health Canada, Canadá Swedish Research Council Formas, Suecia National Institutes of Health(NIH)/National Institute of Environmental Health Sciences (NIEHS), EE.UU Instituto Regional en Estudios en Sustancias Tóxicas

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Environmental Health Perspectives
    Article . 2018 . Peer-reviewed
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Environmental Health Perspectives
    Article
    License: pd
    Data sources: UnpayWall
    addClaim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    Access Routes
    Green
    gold
    41
    citations41
    popularityTop 10%
    influenceAverage
    impulseTop 10%
    BIP!Powered by BIP!
    more_vert
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Environmental Health Perspectives
      Article . 2018 . Peer-reviewed
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Environmental Health Perspectives
      Article
      License: pd
      Data sources: UnpayWall
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: van Wendel de Joode, Berna; Mora, Ana María; Córdoba, Leonel; Cano, Juan Camilo; +8 Authors

    IRET, CERCH Background: Mancozeb and its main metabolite ethylene thiourea (ETU) may alter thyroid function; thyroid hormones are essential for fetal brain development. In Costa Rica, mancozeb is aerially sprayed at large-scale banana plantations on a weekly basis. Objectives: Our goals were to evaluate urinary ETU concentrations in pregnant women living near large-scale banana plantations, compare their estimated daily intake (EDI) with established reference doses (RfDs), and identify factors that predict their urinary ETU concentrations. Methods: We enrolled 451 pregnant women from Matina County, Costa Rica, which has large-scale banana production. We visited 445 women up to three times during pregnancy to obtain urine samples (n = 872) and information on factors that possibly influence exposure. We determined urinary ETU concentrations using liquid chromatography mass spectrometry. Results: Pregnant women’s median urinary ETU concentrations were more than five times higher than those reported for other general populations. Seventy-two percent of the women had EDIs above the RfD. Women who lived closest (1st quartile, < 48m) to banana plantations on average had a 45% (95% CI: 23, 72%) higher urinary ETU compared with women who lived farthest away (4th quartile, ≥ 565m). Compared with the other women, ETU was also higher in women who washed agricultural work clothes on the day before sampling (11%; 95% CI: 4.9, 17%), women who worked in agriculture during pregnancy (19%; 95% CI: 9.3, 29%), and immigrant women (6.2%; 95% CI: 1.0, 13%). Conclusions: The pregnant women’s urinary ETU concentrations are of concern, and the principal source of exposure is likely to be aerial spraying of mancozeb. The factors predicting ETU provide insight into possibilities for exposure reduction. Antecedentes: el mancozeb y su principal metabolito etilen tiourea (ETU) pueden alterar la función tiroidea; Las hormonas tiroideas son esenciales para el desarrollo del cerebro fetal. En Costa Rica, mancozeb se fumiga por vía aérea en plantaciones de banano a gran escala semanalmente. Objetivos: Nuestros objetivos fueron evaluar las concentraciones urinarias de ETU en mujeres embarazadas que viven cerca de grandes plantaciones de banano, comparar su ingesta diaria estimada (EDI) con las dosis de referencia establecidas (RfD) e identificar factores que predicen sus concentraciones urinarias de ETU. Métodos: Inscribimos a 451 mujeres embarazadas del condado de Matina, Costa Rica, que tiene una producción bananera a gran escala. Visitamos a 445 mujeres hasta tres veces durante el embarazo para obtener muestras de orina (n = 872) e información sobre los factores que posiblemente influyen en la exposición. Determinamos las concentraciones urinarias de ETU mediante cromatografía líquida y espectrometría de masas. Resultados: Las concentraciones medias de ETU en orina de las mujeres embarazadas fueron más de cinco veces más altas que las informadas para otras poblaciones generales. Setenta y dos por ciento de las mujeres tenían EDI por encima de la RfD. Las mujeres que vivían más cerca (1er cuartil, <48 m) a las plantaciones de banano en promedio tenían una ETU urinaria un 45% (IC del 95%: 23, 72%) más alta en comparación con las mujeres que vivían más lejos (4to cuartil, ≥ 565 m). En comparación con las otras mujeres, la ETU también fue mayor en las mujeres que lavaron la ropa de trabajo agrícola el día anterior al muestreo (11%; IC del 95%: 4,9; 17%), las mujeres que trabajaron en la agricultura durante el embarazo (19%; IC del 95% : 9,3, 29%) y mujeres inmigrantes (6,2%; IC del 95%: 1,0, 13%). Conclusiones: Las concentraciones urinarias de ETU de las mujeres embarazadas son motivo de preocupación y es probable que la principal fuente de exposición sea la pulverización aérea de mancozeb. Los factores que predicen la ETU proporcionan información sobre las posibilidades de reducción de la exposición. Introdução: O mancozebe e seu principal metabólito etilenotioureia (ETU) podem alterar a função tireoidiana; os hormônios da tireoide são essenciais para o desenvolvimento do cérebro fetal. Na Costa Rica, o mancozeb é pulverizado semanalmente em grandes plantações de banana. Objetivos: Nossos objetivos foram avaliar as concentrações urinárias de ETU em mulheres grávidas que vivem perto de plantações de banana em grande escala, comparar sua ingestão diária estimada (EDI) com as doses de referência estabelecidas (RfDs) e identificar fatores que predizem suas concentrações urinárias de ETU. Métodos: Foram matriculadas 451 gestantes do município de Matina, Costa Rica, que possui grande produção de banana. Visitamos 445 mulheres até três vezes durante a gravidez para obter amostras de urina (n = 872) e informações sobre os fatores que possivelmente influenciam a exposição. Determinamos as concentrações urinárias de ETU usando espectrometria de massa por cromatografia líquida. Resultados: As concentrações urinárias medianas de ETU de mulheres grávidas eram mais de cinco vezes maiores do que as relatadas para outras populações em geral. Setenta e dois por cento das mulheres tinham EDIs acima do RfD. Mulheres que viviam mais próximo (1º quartil, <48m) de plantações de banana em média tiveram uma ETU urinária 45% (IC 95%: 23, 72%) maior em comparação com mulheres que moravam mais longe (4º quartil, ≥ 565m). Em comparação com as outras mulheres, a ETU também foi maior em mulheres que lavaram roupas de trabalho agrícola no dia anterior à amostragem (11%; IC de 95%: 4,9; 17%), mulheres que trabalharam na agricultura durante a gravidez (19%; IC de 95%) : 9,3, 29%), e mulheres imigrantes (6,2%; IC 95%: 1,0, 13%). Conclusões: As concentrações urinárias de ETU das mulheres grávidas são preocupantes e a principal fonte de exposição é provavelmente a pulverização aérea de mancozebe. Os fatores que prevêem a ETU fornecem informações sobre as possibilidades de redução da exposição. Universidad Nacional, Costa Rica University of California, United States Lund University, Sweden Karolinska Institutet, Sweden Université du Québec a Montréal, Canada Instituto Regional de Estudios en Sustancias Tóxicas

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Environmental Health Perspectives
    Article . 2014 . Peer-reviewed
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    addClaim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    Access Routes
    Green
    gold
    68
    citations68
    popularityTop 1%
    influenceTop 10%
    impulseTop 10%
    BIP!Powered by BIP!
    more_vert
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Environmental Health Perspectives
      Article . 2014 . Peer-reviewed
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
Powered by OpenAIRE graph
search
The following results are related to Rural Digital Europe. Are you interested to view more results? Visit OpenAIRE - Explore.
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Liliana A. Zúñiga-Venegas; Carly Hyland; María Teresa Muñoz-Quezada; Lesliam Quirós-Alcalá; +18 Authors

    BACKGROUND: Multiple epidemiological studies have shown that exposure to pesticides is associated with adverse health outcomes. However, the literature on pesticide-related health effects in the Latin American and the Caribbean (LAC) region, an area of intensive agricultural and residential pesticide use, is sparse. We conducted a scoping review to describe the current state of research on the health effects of pesticide exposure in LAC populations with the goal of identifying knowledge gaps and research capacity building needs. METHODS: We searched PubMed and SciELO for epidemiological studies on pesticide exposure and human health in LAC populations published between January 2007 and December 2021. We identified 233 publications from 16 countries that met our inclusion criteria and grouped them by health outcome (genotoxicity, neurobehavioral outcomes, placental outcomes and teratogenicity, cancer, thyroid function, reproductive outcomes, birth outcomes and child growth, and others). RESULTS: Most published studies were conducted in Brazil (37%, n = 88) and Mexico (20%, n = 46), were cross-sectional in design (72%, n = 167), and focused on farmworkers (45%, n = 105) or children (21%, n = 48). The most frequently studied health effects included genotoxicity (24%, n = 62) and neurobehavioral outcomes (21%, n = 54), and organophosphate (OP) pesticides were the most frequently examined (26%, n = 81). Forty-seven percent (n = 112) of the studies relied only on indirect pesticide exposure assessment methods. Exposure to OP pesticides, carbamates, or to multiple pesticide classes was consistently associated with markers of genotoxicity and adverse neurobehavioral outcomes, particularly among children and farmworkers. DISCUSSION: Our scoping review provides some evidence that exposure to pesticides may adversely impact the health of LAC populations, but methodological limitations and inconsistencies undermine the strength of the conclusions. It is critical to increase capacity building, integrate research initiatives, and conduct more rigorous epidemiological studies in the region to address these limitations, better inform public health surveillance systems, and maximize the impact of research on public policies. Fil: Cortés, Sandra. Pontificia Universidad Católica de Chile. Departamento de Salud Pública. Centro de Desarrollo Urbano Sustentable. Centro Avanzado de Enfermedades Crónicas (ACCDiS); Chile Fil: Muñoz-Quezada, María Teresa. Universidad Católica del Maule. Facultad de Ciencias de la Salud. Centro de Investigación en Neuropsicología y Neurociencias Cognitivas; Chile Fil: Lucero, Boris A. Universidad Católica del Maule. Facultad de Ciencias de la Salud. Centro de Investigación en Neuropsicología y Neurociencias Cognitivas; Chile Fil: de Joode, Berna van Wendel. Universidad Nacional. Central American Institute for Studies on Toxic Substances. Infants’ Environmental Health Study; Costa Rica Fil: Quirós-Alcalá, Lesliam. John Hopkins University. Bloomberg School of Public Health. Department of Environmental Health and Engineering; Estados Unidos Fil: Mora, Ana M. Universidad Nacional. Central American Institute for Studies on Toxic Substances. Infants’ Environmental Health Study; Costa Rica Fil: Quirós-Alcalá, Lesliam. University of Maryland. School of Public Health. Maryland Institute of Applied Environmental Health; Estados Unidos Fil: Cardenas, Andres. University of California. School of Public Health. Center for Environmental Research and Community Health; Estados Unidos Fil: Smith, Anna R. University of California. School of Public Health. Center for Environmental Research and Community Health; Estados Unidos Fil: Hyland, Carly. University of California. School of Public Health. Center for Environmental Research and Community Health; Estados Unidos Fil: Mora, Ana M. University of California. School of Public Health. Center for Environmental Research and Community Health; Estados Unidos Fil: Zúñiga-Venegas, Liliana A. Universidad Católica del Maule. Centro de Investigaciones de Estudios Avanzados del Maule; Chile Fil: Jara, Juan P. Gutiérrez. Universidad Católica del Maule. Centro de Investigaciones de Estudios Avanzados del Maule; Chile Fil: Foerster, Claudia. Universidad de O’Higgins. Instituto de Ciencias de la Agroalimentarias, Animales y Ambientales; Chile Fil: Ramírez-Santana, Muriel. Universidad Católica del Norte. Facultad de Medicina. Departamento de Salud Pública; Chile Fil: Buralli, Rafael. Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Saúde Ambiental; Brasil Fil: Gouveia, Nelson. Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Preventiva; Brasil Fil: Handal, Alexis J. University of Michigan School of Public Health. Department of Epidemiology; Estados Unidos Fil: Hyland, Carly. Boise State University. School of Public Health and Population Science; Estados Unidos Fil: Tirado, Noemi. Universidad Mayor de San Andrés. Facultad de Medicina. Instituto de Genética; Bolivia Fil: Fernandez, Ricardo A. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina Fil: Muñoz, María Pía. Universidad de Chile. Facultad de Medicina. Escuela de Salud Pública; Chile Fil: Butinof, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina Fil: Calaf, Gloria M. Universidad de Tarapacá. Instituto de Alta Investigación; Chile Fil: da Silva, Agnes Soares. Pan American Health Organization. Estados Unidos Fil: Calaf, Gloria M. Columbia University Medical Center; Estados Unidos

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Producción Académica...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Environmental Health Perspectives
    Article . 2022 . Peer-reviewed
    Data sources: Crossref
    addClaim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    2
    citations2
    popularityAverage
    influenceAverage
    impulseAverage
    BIP!Powered by BIP!
    more_vert
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Producción Académica...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Environmental Health Perspectives
      Article . 2022 . Peer-reviewed
      Data sources: Crossref
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Ana M. Mora; Leonel Córdoba; Juan Camilo Cano; David Hernández-Bonilla; +8 Authors

    Programa Infantes y Salud Ambiental Programa ISA Infant´s Environmental Health Study Infant´s Environmental Health Program BACKGROUND: Although growing evidence suggests that early-life excess manganese (Mn) impairs neurodevelopment, data on the neurodevelopmental effects of mancozeb, a fungicide containing Mn, and its main metabolite ethylenethiourea (ETU) are limited. OBJECTIVE: We examined whether prenatal mancozeb exposure and excess Mn were associated with neurodevelopment in 355 1-y-old infants living near banana plantations with frequent aerial mancozeb spraying in Costa Rica. METHODS: We measured urinary ETU, hair Mn, and blood Mn concentrations in samples collected 1–3 times during pregnancy from mothers enrolled in the Infants’ Environmental Health (ISA) study. We then assessed neurodevelopment in their 1-y-old infants using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). We estimated exposure–outcome associations using linear regression models adjusted for maternal education, parity, gestational age at birth, child age, Home Observation for Measurement of the Environment score, and location of neurodevelopmental assessment. RESULTS: Median (P25–P75) urinary ETU, hair Mn, and blood Mn measured during pregnancy were 3:3 lg=L (2.4–4.9; specific gravity–corrected), 1:7 lg=g (0.9–4.1), and 24:0 lg=L (20.3–28.0), respectively. Among girls, higher ETU was associated with lower social-emotional scores [b per 10-fold increase= −7:4 points (95% CI: −15:2, 0.4)], whereas higher hair Mn was associated with lower cognitive scores [−3:0 (−6:1, 0.1)]. Among boys, higher hair Mn was associated with lower social-emotional scores [−4:6 (−8:5, −0:8)]. We observed null associations for blood Mn, language, and motor outcomes. CONCLUSIONS: Our findings indicate that maternal exposure to mancozeb and excess Mn during pregnancy may have adverse and sex-specific effects on infant neurodevelopment. ANTECEDENTES: Aunque la evidencia creciente sugiere que el exceso de manganeso (Mn) en las primeras etapas de la vida afecta el desarrollo neurológico, los datos sobre los efectos del desarrollo neurológico de mancozeb, un fungicida que contiene Mn, y su principal metabolito etilentiourea (ETU) son limitados. OBJETIVO: Examinamos si la exposición prenatal a mancozeb y el exceso de Mn estaban asociados con el desarrollo neurológico en 355 bebés de 1 año que vivían cerca de plantaciones de banano con fumigación aérea frecuente de mancozeb en Costa Rica. MÉTODOS: Medimos las concentraciones de ETU urinaria, Mn en el cabello y Mn en sangre en muestras recolectadas de 1 a 3 veces durante el embarazo de madres inscritas en el estudio Infants ’Environmental Health (ISA). Luego evaluamos el desarrollo neurológico en sus bebés de 1 año utilizando las Escalas de Bayley para bebés y niños pequeños Desarrollo, 3ª edición (BSID-III). Estimamos las asociaciones exposición-resultado utilizando modelos de regresión lineal ajustados por educación materna, paridad, edad gestacional al nacer, edad del niño, observación en el hogar para medir el puntaje ambiental y ubicación de la evaluación del desarrollo neurológico. RESULTADOS: La ETU urinaria mediana (P25-P75), el Mn del cabello y el Mn en sangre medidos durante el embarazo fueron 3: 3 lg = L (2.4-4.9; gravedad específica corregida), 1: 7 lg = g (0.9-4.1), y 24: 0 lg = L (20,3-28,0), respectivamente. Entre las niñas, una ETU más alta se asoció con puntuaciones socioemocionales más bajas [b por aumento de 10 veces = −7: 4 puntos (IC del 95%: −15: 2, 0,4)], mientras que una mayor Mn de cabello se asoció con puntuaciones cognitivas más bajas [−3: 0 (−6: 1, 0,1)]. Entre los niños, una mayor cantidad de cabello Mn se asoció con puntuaciones socioemocionales más bajas [−4: 6 (−8: 5, −0: 8)]. Observamos asociaciones nulas para Mn en sangre, lenguaje y resultados motores. CONCLUSIONES: Nuestros hallazgos indican que la exposición materna al mancozeb y el exceso de Mn durante el embarazo pueden tener efectos adversos y específicos del sexo en el desarrollo neurológico infantil. Universidad Nacional, Costa Rica Ministerio de Ciencia, Tecnología y Telecomunicaciones (MICITT), Costa Rica International Development Research Centre (IDRC), Canadá Health Canada, Canadá Swedish Research Council Formas, Suecia National Institutes of Health(NIH)/National Institute of Environmental Health Sciences (NIEHS), EE.UU Instituto Regional en Estudios en Sustancias Tóxicas

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Environmental Health Perspectives
    Article . 2018 . Peer-reviewed
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Environmental Health Perspectives
    Article
    License: pd
    Data sources: UnpayWall
    addClaim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    Access Routes
    Green
    gold
    41
    citations41
    popularityTop 10%
    influenceAverage
    impulseTop 10%
    BIP!Powered by BIP!
    more_vert
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Environmental Health Perspectives
      Article . 2018 . Peer-reviewed
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Environmental Health Perspectives
      Article
      License: pd
      Data sources: UnpayWall
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: van Wendel de Joode, Berna; Mora, Ana María; Córdoba, Leonel; Cano, Juan Camilo; +8 Authors

    IRET, CERCH Background: Mancozeb and its main metabolite ethylene thiourea (ETU) may alter thyroid function; thyroid hormones are essential for fetal brain development. In Costa Rica, mancozeb is aerially sprayed at large-scale banana plantations on a weekly basis. Objectives: Our goals were to evaluate urinary ETU concentrations in pregnant women living near large-scale banana plantations, compare their estimated daily intake (EDI) with established reference doses (RfDs), and identify factors that predict their urinary ETU concentrations. Methods: We enrolled 451 pregnant women from Matina County, Costa Rica, which has large-scale banana production. We visited 445 women up to three times during pregnancy to obtain urine samples (n = 872) and information on factors that possibly influence exposure. We determined urinary ETU concentrations using liquid chromatography mass spectrometry. Results: Pregnant women’s median urinary ETU concentrations were more than five times higher than those reported for other general populations. Seventy-two percent of the women had EDIs above the RfD. Women who lived closest (1st quartile, < 48m) to banana plantations on average had a 45% (95% CI: 23, 72%) higher urinary ETU compared with women who lived farthest away (4th quartile, ≥ 565m). Compared with the other women, ETU was also higher in women who washed agricultural work clothes on the day before sampling (11%; 95% CI: 4.9, 17%), women who worked in agriculture during pregnancy (19%; 95% CI: 9.3, 29%), and immigrant women (6.2%; 95% CI: 1.0, 13%). Conclusions: The pregnant women’s urinary ETU concentrations are of concern, and the principal source of exposure is likely to be aerial spraying of mancozeb. The factors predicting ETU provide insight into possibilities for exposure reduction. Antecedentes: el mancozeb y su principal metabolito etilen tiourea (ETU) pueden alterar la función tiroidea; Las hormonas tiroideas son esenciales para el desarrollo del cerebro fetal. En Costa Rica, mancozeb se fumiga por vía aérea en plantaciones de banano a gran escala semanalmente. Objetivos: Nuestros objetivos fueron evaluar las concentraciones urinarias de ETU en mujeres embarazadas que viven cerca de grandes plantaciones de banano, comparar su ingesta diaria estimada (EDI) con las dosis de referencia establecidas (RfD) e identificar factores que predicen sus concentraciones urinarias de ETU. Métodos: Inscribimos a 451 mujeres embarazadas del condado de Matina, Costa Rica, que tiene una producción bananera a gran escala. Visitamos a 445 mujeres hasta tres veces durante el embarazo para obtener muestras de orina (n = 872) e información sobre los factores que posiblemente influyen en la exposición. Determinamos las concentraciones urinarias de ETU mediante cromatografía líquida y espectrometría de masas. Resultados: Las concentraciones medias de ETU en orina de las mujeres embarazadas fueron más de cinco veces más altas que las informadas para otras poblaciones generales. Setenta y dos por ciento de las mujeres tenían EDI por encima de la RfD. Las mujeres que vivían más cerca (1er cuartil, <48 m) a las plantaciones de banano en promedio tenían una ETU urinaria un 45% (IC del 95%: 23, 72%) más alta en comparación con las mujeres que vivían más lejos (4to cuartil, ≥ 565 m). En comparación con las otras mujeres, la ETU también fue mayor en las mujeres que lavaron la ropa de trabajo agrícola el día anterior al muestreo (11%; IC del 95%: 4,9; 17%), las mujeres que trabajaron en la agricultura durante el embarazo (19%; IC del 95% : 9,3, 29%) y mujeres inmigrantes (6,2%; IC del 95%: 1,0, 13%). Conclusiones: Las concentraciones urinarias de ETU de las mujeres embarazadas son motivo de preocupación y es probable que la principal fuente de exposición sea la pulverización aérea de mancozeb. Los factores que predicen la ETU proporcionan información sobre las posibilidades de reducción de la exposición. Introdução: O mancozebe e seu principal metabólito etilenotioureia (ETU) podem alterar a função tireoidiana; os hormônios da tireoide são essenciais para o desenvolvimento do cérebro fetal. Na Costa Rica, o mancozeb é pulverizado semanalmente em grandes plantações de banana. Objetivos: Nossos objetivos foram avaliar as concentrações urinárias de ETU em mulheres grávidas que vivem perto de plantações de banana em grande escala, comparar sua ingestão diária estimada (EDI) com as doses de referência estabelecidas (RfDs) e identificar fatores que predizem suas concentrações urinárias de ETU. Métodos: Foram matriculadas 451 gestantes do município de Matina, Costa Rica, que possui grande produção de banana. Visitamos 445 mulheres até três vezes durante a gravidez para obter amostras de urina (n = 872) e informações sobre os fatores que possivelmente influenciam a exposição. Determinamos as concentrações urinárias de ETU usando espectrometria de massa por cromatografia líquida. Resultados: As concentrações urinárias medianas de ETU de mulheres grávidas eram mais de cinco vezes maiores do que as relatadas para outras populações em geral. Setenta e dois por cento das mulheres tinham EDIs acima do RfD. Mulheres que viviam mais próximo (1º quartil, <48m) de plantações de banana em média tiveram uma ETU urinária 45% (IC 95%: 23, 72%) maior em comparação com mulheres que moravam mais longe (4º quartil, ≥ 565m). Em comparação com as outras mulheres, a ETU também foi maior em mulheres que lavaram roupas de trabalho agrícola no dia anterior à amostragem (11%; IC de 95%: 4,9; 17%), mulheres que trabalharam na agricultura durante a gravidez (19%; IC de 95%) : 9,3, 29%), e mulheres imigrantes (6,2%; IC 95%: 1,0, 13%). Conclusões: As concentrações urinárias de ETU das mulheres grávidas são preocupantes e a principal fonte de exposição é provavelmente a pulverização aérea de mancozebe. Os fatores que prevêem a ETU fornecem informações sobre as possibilidades de redução da exposição. Universidad Nacional, Costa Rica University of California, United States Lund University, Sweden Karolinska Institutet, Sweden Université du Québec a Montréal, Canada Instituto Regional de Estudios en Sustancias Tóxicas

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Environmental Health Perspectives
    Article . 2014 . Peer-reviewed
    Data sources: Crossref
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    addClaim

    This Research product is the result of merged Research products in OpenAIRE.

    You have already added works in your ORCID record related to the merged Research product.
    Access Routes
    Green
    gold
    68
    citations68
    popularityTop 1%
    influenceTop 10%
    impulseTop 10%
    BIP!Powered by BIP!
    more_vert
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Europe PubMed Centra...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      Environmental Health Perspectives
      Article . 2014 . Peer-reviewed
      Data sources: Crossref
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      addClaim

      This Research product is the result of merged Research products in OpenAIRE.

      You have already added works in your ORCID record related to the merged Research product.
Powered by OpenAIRE graph