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description Publicationkeyboard_double_arrow_right Other literature type , Article 2021 Switzerland, NetherlandsPublisher:F1000 Research Ltd Funded by:WT | Spot SepsisWT| Spot SepsisArjun Chandna; Nan Shwe Nwe Htun; Thomas J. Peto; Marco Liverani; Tobias Brummaier; Koukeo Phommasone; Sazid Ibna Zaman; Aye Sandar Zaw; Elizabeth M. Batty; Naomi Waithira; Melissa Richard-Greenblatt; Stuart D. Blacksell; Ladaporn Bodhidatta; James J. Callery; Watcharintorn Fagnark; Shayla Islam; Sanchai Lertcharoenchoke; Mavuto Mukaka; Tiengkham Pongvongsa; William Hk Schilling; Janjira Thaipadungpanit; Rupam Tripura; Arjen M. Dondorp; Mayfong Mayxay; Nicholas J. White; François Nosten; Frank Smithuis; Elizabeth A. Ashley; Richard J. Maude; Nicholas P. J. Day; Yoel Lubell;In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity and mortality. Village health workers (VHWs) are often the first point of contact with the formal health system, and for patients with febrile illnesses they can provide early diagnosis and treatment of malaria. However, for the majority of febrile patients, VHWs lack the training, support and resources to provide further care. Consequently, treatable bacterial illnesses are missed, antibiotics are overused and poorly targeted, and patient attendance wanes along with declining malaria. This Open Letter announces the start of a new initiative, the Rural Febrile Illness (RFI) project, the first in a series of projects to be implemented as part of the South and Southeast Asian Community-based Trials Network (SEACTN) research programme. This multi-country, multi-site project will run in Bangladesh, Cambodia, Lao PDR, Thailand, and Myanmar. It will define the epidemiological baseline of febrile illness in nine remote and underserved areas of Asia where malaria endemicity is declining and access to health services is limited. The RFI project aims to determine the incidence, causes and outcomes of febrile illness; understand the opportunities, barriers and appetite for adjustment of the role of VHWs to include management of non-malarial febrile illnesses; and establish a network of community healthcare providers and facilities capable of implementing interventions designed to triage, diagnose and treat patients presenting with febrile illnesses within these communities in the future.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8080974Data sources: PubMed CentralCORE (RIOXX-UK Aggregator)Article . 2021Full-Text: http://oro.open.ac.uk/77705/1/77705.pdfData sources: CORE (RIOXX-UK Aggregator)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8080974Data sources: PubMed CentralCORE (RIOXX-UK Aggregator)Article . 2021Full-Text: http://oro.open.ac.uk/77705/1/77705.pdfData sources: CORE (RIOXX-UK Aggregator)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, United Kingdom, SwedenPublisher:MDPI AG Funded by:WTWTDyna Doum; Hans J. Overgaard; Mayfong Mayxay; Sutas Suttiprapa; Prasert Saichua; Tipaya Ekalaksananan; Panwad Tongchai; Siddikur Rahman; Ubydul Haque; Sysavanh Phommachanh; Tiengkham Pongvongsa; Joacim Rocklöv; Richard Paul; Chamsai Pientong;pmc: PMC7731008 , PMC7913739
Dengue is the most rapidly spreading mosquito-borne viral disease in the world. The detection of clinical cases enables us to measure the incidence of dengue infection, whereas serological surveys give insights into the prevalence of infection. This study aimed to determine dengue seroprevalence and seroconversion rates in northeastern Thailand and southern Laos and to assess any association of mosquito control methods and socioeconomic factors with dengue virus (DENV) infection. Cross-sectional seroprevalence surveys were performed in May and November 2019 on the same individuals. Blood samples were collected from one adult and one child, when possible, in each of 720 randomly selected households from two urban and two rural sites in both northeastern Thailand and southern Laos. IgG antibodies against DENV were detected in serum using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Overall, 1071 individuals participated in the study. The seroprevalence rate was high (91.5%) across all 8 study sites. Only age and province were associated with seroprevalence rates. There were 33 seroconversions during the period from May to November, of which seven reported fever. More than half of the seroconversions occurred in the rural areas and in Laos. Dengue seroconversion was significantly associated with young age (<15 years old), female gender, province, and duration of living in the current residence. No socioeconomic factors or mosquito control methods were found to be associated with seroprevalence or seroconversion. Notably, however, the province with most seroconversions had lower diurnal temperature ranges than elsewhere. In conclusion, our study has highlighted the homogeneity of dengue exposure across a wide range of settings and most notably those from rural and urban areas. Dengue can no longer be considered to be solely an urban disease nor necessarily one linked to poverty. Errata: Doum D, Overgaard HJ, Mayxay M, Suttiprapa S, Saichua P, Ekalaksananan T, Tongchai P, Rahman MS, Haque U, Phommachanh S, Pongvongsa T, Rocklöv J, Paul R, Pientong C. Correction: Doum, D., et al. Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos. Int. J. Environ. Res. Public Health 2020, 17, 9134. International Journal of Environmental Research and Public Health. 2021; 18(4):1439. DOI: 10.3390/ijerph18041439
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2020 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/1660-4601/17/23/9134/pdfInternational Journal of Environmental Research and Public HealthArticle . 2020Full-Text: http://europepmc.org/articles/PMC7731008Data sources: PubMed CentralEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7913739Data sources: PubMed CentralInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveInternational Journal of Environmental Research and Public HealthArticle . 2020Data sources: DOAJ-ArticlesHAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BYFull-Text: https://hal.science/hal-03533005/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 2visibility views 2 download downloads 3 Powered bymore_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2020 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/1660-4601/17/23/9134/pdfInternational Journal of Environmental Research and Public HealthArticle . 2020Full-Text: http://europepmc.org/articles/PMC7731008Data sources: PubMed CentralEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7913739Data sources: PubMed CentralInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveInternational Journal of Environmental Research and Public HealthArticle . 2020Data sources: DOAJ-ArticlesHAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BYFull-Text: https://hal.science/hal-03533005/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 France, United States, United KingdomPublisher:Public Library of Science (PLoS) Funded by:WT | Thailand Major Overseas P...WT| Thailand Major Overseas Programme core grant renewal 2015-2020.Sayaphet Rattanavong; Audrey Dubot-Pérès; Mayfong Mayxay; Manivanh Vongsouvath; Sue J. Lee; Julien Cappelle; Paul N. Newton; Daniel M. Parker;Background: Central nervous system (CNS) infections are important contributors to morbidity and mortality and the causative agents for ~50% patients are never identified. The causative agents of some CNS infections have distinct spatial and temporal patterns.Methodology/principal findings: Here we present the results of a spatial epidemiological and ecological analysis of CNS infections in Lao PDR (2003-2011). The data came from hospitalizations for suspected CNS infection at Mahosot Hospital in Vientiane. Out of 1,065 patients, 450 were assigned a confirmed diagnosis. While many communities in Lao PDR are in rural and remote locations, most patients in these data came from villages along major roads. Japanese encephalitis virus ((JEV); n = 94) and Cryptococcus spp. (n = 70) were the most common infections. JEV infections peaked in the rainy season and JEV patients came from villages with higher surface flooding during the same month as admission. JEV infections were spatially dispersed throughout rural areas and were most common in children. Cryptococcus spp. infections clustered near Vientiane (an urban area) and among adults.Conclusions/significance: The spatial and temporal patterns identified in this analysis are related to complex environmental, social, and geographic factors. For example, JEV infected patients came from locations with environmental conditions (surface water) that are suitable to support larger mosquito vector populations. Most patients in these data came from villages that are near major roads; likely the result of geographic and financial access to healthcare and also indicating that CNS diseases are underestimated in the region (especially from more remote areas). As Lao PDR is undergoing major developmental and environmental changes, the space-time distributions of the causative agents of CNS infection will also likely change. There is a major need for increased diagnostic abilities; increased access to healthcare, especially for rural populations; and for increased surveillance throughout the nation. International audience
Mémoires en Sciences... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7274481Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of CaliforniaPLoS Neglected Tropical Diseases; Oxford University Research ArchiveArticle . 2020 . Peer-reviewedLicense: CC BYHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold more_vert Mémoires en Sciences... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7274481Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of CaliforniaPLoS Neglected Tropical Diseases; Oxford University Research ArchiveArticle . 2020 . Peer-reviewedLicense: CC BYHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pntd.0008333&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2019Publisher:Cold Spring Harbor Laboratory Funded by:WT | Thailand Major Overseas P...WT| Thailand Major Overseas Programme core grant renewal 2015-2020.Sayaphet Rattanavong; Audrey Dubot-Pérès; Mayfong Mayxay; Manivanh Vongsouvath; Sue J. Lee; Julien Cappelle; Paul N. Newton; Daniel M. Parker;doi: 10.1101/19005884
ABSTRACTBackgroundCentral nervous system (CNS) infections are important contributors to morbidity and mortality and the causative agents for ∼50% patients are never identified. The causative agents of some CNS infections have distinct spatial and temporal patterns.Methodology/Principal FindingsHere we present the results of a spatial epidemiological and ecological analysis of CNS infections in Lao PDR (2003 – 2011). The data came from hospitalizations for suspected CNS infection at Mahosot Hospital in Vientiane. Out of 1,065 patients, 450 were assigned a confirmed diagnosis. While many communities in Lao PDR are in rural and remote locations, most patients in these data came from villages along major roads. Japanese encephalitis virus ((JEV); n=94) and Cryptococcus spp. (n=70) were the most common infections. JEV infections peaked in the rainy season and JEV patients came from villages with higher surface flooding during the same month as admission. JEV infections were spatially dispersed throughout rural areas and were most common in children. Cryptococcus spp. infections clustered near Vientiane (an urban area) and among adults.Conclusions/SignificanceThe spatial and temporal patterns identified in this analysis are related to complex environmental, social, and geographic factors. For example, JEV infected patients came from locations with environmental conditions (surface water) that are suitable to support larger mosquito vector populations. Most patients in these data came from villages that are near major roads; likely the result of geographic and financial access to healthcare and also indicating that CNS diseases are underestimated in the region (especially from more remote areas). As Lao PDR is undergoing major developmental and environmental changes, the space-time distributions of the causative agents of CNS infection will also likely change. There is a major need for increased diagnostic abilities; increased access to healthcare, especially for rural populations; and for increased surveillance throughout the nation.AUTHOR SUMMARYInfections of the central nervous system (CNS) are important with regard to public health. However many CNS infections are never diagnosed. In this analysis we investigated spatial and temporal patterns in hospitalized patients with suspected CNS infections in Lao PDR. We found that patients were most likely to come from villages located along major roads and highways. Patients from remote areas may have more difficulty reaching healthcare facilities. The most commonly diagnosed infection in these patients was Japanese encephalitis virus (JEV). Patients with this disease came from locations that were optimal for the mosquito vectors that spread JEV, rural areas with surface water and during the rainy season. Our analyses suggest that CNS infections should be a priority for public health workers in the region. Diagnostic capabilities should be increased throughout the nation; surveillance efforts should be broadened; and efforts should be increased toward providing easy access to healthcare for rural and remote populations.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Other literature type , Article 2021 Switzerland, NetherlandsPublisher:F1000 Research Ltd Funded by:WT | Spot SepsisWT| Spot SepsisArjun Chandna; Nan Shwe Nwe Htun; Thomas J. Peto; Marco Liverani; Tobias Brummaier; Koukeo Phommasone; Sazid Ibna Zaman; Aye Sandar Zaw; Elizabeth M. Batty; Naomi Waithira; Melissa Richard-Greenblatt; Stuart D. Blacksell; Ladaporn Bodhidatta; James J. Callery; Watcharintorn Fagnark; Shayla Islam; Sanchai Lertcharoenchoke; Mavuto Mukaka; Tiengkham Pongvongsa; William Hk Schilling; Janjira Thaipadungpanit; Rupam Tripura; Arjen M. Dondorp; Mayfong Mayxay; Nicholas J. White; François Nosten; Frank Smithuis; Elizabeth A. Ashley; Richard J. Maude; Nicholas P. J. Day; Yoel Lubell;In rural areas of South and Southeast Asia malaria is declining but febrile illnesses still account for substantial morbidity and mortality. Village health workers (VHWs) are often the first point of contact with the formal health system, and for patients with febrile illnesses they can provide early diagnosis and treatment of malaria. However, for the majority of febrile patients, VHWs lack the training, support and resources to provide further care. Consequently, treatable bacterial illnesses are missed, antibiotics are overused and poorly targeted, and patient attendance wanes along with declining malaria. This Open Letter announces the start of a new initiative, the Rural Febrile Illness (RFI) project, the first in a series of projects to be implemented as part of the South and Southeast Asian Community-based Trials Network (SEACTN) research programme. This multi-country, multi-site project will run in Bangladesh, Cambodia, Lao PDR, Thailand, and Myanmar. It will define the epidemiological baseline of febrile illness in nine remote and underserved areas of Asia where malaria endemicity is declining and access to health services is limited. The RFI project aims to determine the incidence, causes and outcomes of febrile illness; understand the opportunities, barriers and appetite for adjustment of the role of VHWs to include management of non-malarial febrile illnesses; and establish a network of community healthcare providers and facilities capable of implementing interventions designed to triage, diagnose and treat patients presenting with febrile illnesses within these communities in the future.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8080974Data sources: PubMed CentralCORE (RIOXX-UK Aggregator)Article . 2021Full-Text: http://oro.open.ac.uk/77705/1/77705.pdfData sources: CORE (RIOXX-UK Aggregator)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8080974Data sources: PubMed CentralCORE (RIOXX-UK Aggregator)Article . 2021Full-Text: http://oro.open.ac.uk/77705/1/77705.pdfData sources: CORE (RIOXX-UK Aggregator)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/wellcomeopenres.16393.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 France, United Kingdom, SwedenPublisher:MDPI AG Funded by:WTWTDyna Doum; Hans J. Overgaard; Mayfong Mayxay; Sutas Suttiprapa; Prasert Saichua; Tipaya Ekalaksananan; Panwad Tongchai; Siddikur Rahman; Ubydul Haque; Sysavanh Phommachanh; Tiengkham Pongvongsa; Joacim Rocklöv; Richard Paul; Chamsai Pientong;pmc: PMC7731008 , PMC7913739
Dengue is the most rapidly spreading mosquito-borne viral disease in the world. The detection of clinical cases enables us to measure the incidence of dengue infection, whereas serological surveys give insights into the prevalence of infection. This study aimed to determine dengue seroprevalence and seroconversion rates in northeastern Thailand and southern Laos and to assess any association of mosquito control methods and socioeconomic factors with dengue virus (DENV) infection. Cross-sectional seroprevalence surveys were performed in May and November 2019 on the same individuals. Blood samples were collected from one adult and one child, when possible, in each of 720 randomly selected households from two urban and two rural sites in both northeastern Thailand and southern Laos. IgG antibodies against DENV were detected in serum using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Overall, 1071 individuals participated in the study. The seroprevalence rate was high (91.5%) across all 8 study sites. Only age and province were associated with seroprevalence rates. There were 33 seroconversions during the period from May to November, of which seven reported fever. More than half of the seroconversions occurred in the rural areas and in Laos. Dengue seroconversion was significantly associated with young age (<15 years old), female gender, province, and duration of living in the current residence. No socioeconomic factors or mosquito control methods were found to be associated with seroprevalence or seroconversion. Notably, however, the province with most seroconversions had lower diurnal temperature ranges than elsewhere. In conclusion, our study has highlighted the homogeneity of dengue exposure across a wide range of settings and most notably those from rural and urban areas. Dengue can no longer be considered to be solely an urban disease nor necessarily one linked to poverty. Errata: Doum D, Overgaard HJ, Mayxay M, Suttiprapa S, Saichua P, Ekalaksananan T, Tongchai P, Rahman MS, Haque U, Phommachanh S, Pongvongsa T, Rocklöv J, Paul R, Pientong C. Correction: Doum, D., et al. Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos. Int. J. Environ. Res. Public Health 2020, 17, 9134. International Journal of Environmental Research and Public Health. 2021; 18(4):1439. DOI: 10.3390/ijerph18041439
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2020 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/1660-4601/17/23/9134/pdfInternational Journal of Environmental Research and Public HealthArticle . 2020Full-Text: http://europepmc.org/articles/PMC7731008Data sources: PubMed CentralEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7913739Data sources: PubMed CentralInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveInternational Journal of Environmental Research and Public HealthArticle . 2020Data sources: DOAJ-ArticlesHAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BYFull-Text: https://hal.science/hal-03533005/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 2visibility views 2 download downloads 3 Powered bymore_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthOther literature type . Article . 2020 . Peer-reviewedLicense: CC BYFull-Text: http://www.mdpi.com/1660-4601/17/23/9134/pdfInternational Journal of Environmental Research and Public HealthArticle . 2020Full-Text: http://europepmc.org/articles/PMC7731008Data sources: PubMed CentralEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7913739Data sources: PubMed CentralInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticleLicense: CC BYData sources: UnpayWallInternational Journal of Environmental Research and Public HealthArticle . 2021 . Peer-reviewedLicense: CC BYData sources: CrossrefInternational Journal of Environmental Research and Public HealthArticle . 2021Data sources: DOAJ-ArticlesOxford University Research ArchiveArticle . 2021License: CC BYData sources: Oxford University Research ArchiveInternational Journal of Environmental Research and Public HealthArticle . 2020Data sources: DOAJ-ArticlesHAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2020License: CC BYFull-Text: https://hal.science/hal-03533005/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 France, United States, United KingdomPublisher:Public Library of Science (PLoS) Funded by:WT | Thailand Major Overseas P...WT| Thailand Major Overseas Programme core grant renewal 2015-2020.Sayaphet Rattanavong; Audrey Dubot-Pérès; Mayfong Mayxay; Manivanh Vongsouvath; Sue J. Lee; Julien Cappelle; Paul N. Newton; Daniel M. Parker;Background: Central nervous system (CNS) infections are important contributors to morbidity and mortality and the causative agents for ~50% patients are never identified. The causative agents of some CNS infections have distinct spatial and temporal patterns.Methodology/principal findings: Here we present the results of a spatial epidemiological and ecological analysis of CNS infections in Lao PDR (2003-2011). The data came from hospitalizations for suspected CNS infection at Mahosot Hospital in Vientiane. Out of 1,065 patients, 450 were assigned a confirmed diagnosis. While many communities in Lao PDR are in rural and remote locations, most patients in these data came from villages along major roads. Japanese encephalitis virus ((JEV); n = 94) and Cryptococcus spp. (n = 70) were the most common infections. JEV infections peaked in the rainy season and JEV patients came from villages with higher surface flooding during the same month as admission. JEV infections were spatially dispersed throughout rural areas and were most common in children. Cryptococcus spp. infections clustered near Vientiane (an urban area) and among adults.Conclusions/significance: The spatial and temporal patterns identified in this analysis are related to complex environmental, social, and geographic factors. For example, JEV infected patients came from locations with environmental conditions (surface water) that are suitable to support larger mosquito vector populations. Most patients in these data came from villages that are near major roads; likely the result of geographic and financial access to healthcare and also indicating that CNS diseases are underestimated in the region (especially from more remote areas). As Lao PDR is undergoing major developmental and environmental changes, the space-time distributions of the causative agents of CNS infection will also likely change. There is a major need for increased diagnostic abilities; increased access to healthcare, especially for rural populations; and for increased surveillance throughout the nation. International audience
Mémoires en Sciences... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7274481Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of CaliforniaPLoS Neglected Tropical Diseases; Oxford University Research ArchiveArticle . 2020 . Peer-reviewedLicense: CC BYHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pntd.0008333&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold more_vert Mémoires en Sciences... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7274481Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of CaliforniaPLoS Neglected Tropical Diseases; Oxford University Research ArchiveArticle . 2020 . Peer-reviewedLicense: CC BYHAL-Inserm; Hal-DiderotArticle . 2020add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pntd.0008333&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2019Publisher:Cold Spring Harbor Laboratory Funded by:WT | Thailand Major Overseas P...WT| Thailand Major Overseas Programme core grant renewal 2015-2020.Sayaphet Rattanavong; Audrey Dubot-Pérès; Mayfong Mayxay; Manivanh Vongsouvath; Sue J. Lee; Julien Cappelle; Paul N. Newton; Daniel M. Parker;doi: 10.1101/19005884
ABSTRACTBackgroundCentral nervous system (CNS) infections are important contributors to morbidity and mortality and the causative agents for ∼50% patients are never identified. The causative agents of some CNS infections have distinct spatial and temporal patterns.Methodology/Principal FindingsHere we present the results of a spatial epidemiological and ecological analysis of CNS infections in Lao PDR (2003 – 2011). The data came from hospitalizations for suspected CNS infection at Mahosot Hospital in Vientiane. Out of 1,065 patients, 450 were assigned a confirmed diagnosis. While many communities in Lao PDR are in rural and remote locations, most patients in these data came from villages along major roads. Japanese encephalitis virus ((JEV); n=94) and Cryptococcus spp. (n=70) were the most common infections. JEV infections peaked in the rainy season and JEV patients came from villages with higher surface flooding during the same month as admission. JEV infections were spatially dispersed throughout rural areas and were most common in children. Cryptococcus spp. infections clustered near Vientiane (an urban area) and among adults.Conclusions/SignificanceThe spatial and temporal patterns identified in this analysis are related to complex environmental, social, and geographic factors. For example, JEV infected patients came from locations with environmental conditions (surface water) that are suitable to support larger mosquito vector populations. Most patients in these data came from villages that are near major roads; likely the result of geographic and financial access to healthcare and also indicating that CNS diseases are underestimated in the region (especially from more remote areas). As Lao PDR is undergoing major developmental and environmental changes, the space-time distributions of the causative agents of CNS infection will also likely change. There is a major need for increased diagnostic abilities; increased access to healthcare, especially for rural populations; and for increased surveillance throughout the nation.AUTHOR SUMMARYInfections of the central nervous system (CNS) are important with regard to public health. However many CNS infections are never diagnosed. In this analysis we investigated spatial and temporal patterns in hospitalized patients with suspected CNS infections in Lao PDR. We found that patients were most likely to come from villages located along major roads and highways. Patients from remote areas may have more difficulty reaching healthcare facilities. The most commonly diagnosed infection in these patients was Japanese encephalitis virus (JEV). Patients with this disease came from locations that were optimal for the mosquito vectors that spread JEV, rural areas with surface water and during the rainy season. Our analyses suggest that CNS infections should be a priority for public health workers in the region. Diagnostic capabilities should be increased throughout the nation; surveillance efforts should be broadened; and efforts should be increased toward providing easy access to healthcare for rural and remote populations.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/19005884&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/19005884&type=result"></script>'); --> </script>
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