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description Publicationkeyboard_double_arrow_right Article 2023Publisher:Universidad Autonoma de Yucatan. Facultad de Medicina Veterinaria y Zootecnia Funded by:NIH | CTSA Institutional Mentor...NIH| CTSA Institutional Mentored Career Development Program (KL2)Authors: Faduma Abdullahi Abdirahman; Raphael Githaiga Wahome; Catherine Kaluwa; Jemimah Oduma; +6 AuthorsFaduma Abdullahi Abdirahman; Raphael Githaiga Wahome; Catherine Kaluwa; Jemimah Oduma; Jynette Jynette Nkatha; Angella Adhiambo; Kitoga Byalungwa Kyotos; Brigitte Bagnol; Marieke Rosenbaum; Janetrix Hellen Amuguni;doi: 10.56369/tsaes.3915
<p><strong>Background.</strong> Traditionally, poultry is kept and reared by women in extensive production systems. In Kenya and most developing countries, smallholder poultry productivity is constrained by diseases such as Newcastle disease (ND), which is preventable via a vaccine, yet contributes to significant morbidity and mortality among flocks primarily owned and managed by women in villages. <strong>Objective.</strong> This study aimed to map the Newcastle disease vaccine value chain stakeholders and identify the barriers and opportunities for women's engagement along the Newcastle disease vaccine value chain. <strong>Methodology</strong>. Qualitative data were collected with 15 key informant interviews and four focus group discussions with a total of 42 poultry farmers in Machakos Town sub-county, Kenya. <strong>Results.</strong> The majority of the vaccine value chain consumers were women, and limited information was one of the root causes for not vaccinating their chickens. Vaccines were considered expensive and difficult to access as the production areas were remote from the agrovet shops that retail vaccines. <strong>Implication.</strong> The study showed that women farmers had no financial control to enable vaccine procurement. <strong>Conclusion</strong>. Based on the results the government using the Extension service providers should train smallholder farmers on how to use the ND vaccine. Furthermore, manufacturers of thermo-stable ND vaccines should furnish Agrovet shops with data to enable its adoption in remote areas where the cold chain is unreliable.<strong></strong></p>
Tropical and Subtrop... arrow_drop_down Tropical and Subtropical AgroecosystemsArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Tropical and Subtrop... arrow_drop_down Tropical and Subtropical AgroecosystemsArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.56369/tsaes.3915&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Denmark, United States, SwitzerlandPublisher:MDPI AG Funded by:NIH | Vulnerability of the Adol...NIH| Vulnerability of the Adolescent Brain to Organophosphorus PesticidesMartin Röösli; Samuel Fuhrimann; Aggrey Atuhaire; Hanna-Andrea Rother; James Dabrowski; Brenda Eskenazi; Erik Jørs; Paul C. Jepson; Leslie London; Saloshni Naidoo; Diane S. Rohlman; Ivy Saunyama; Berna van Wendel de Joode; Adeoluwa O. Adeleye; Oyebanji O. Alagbo; Dem Aliaj; Jember Azanaw; Ravichandran Beerappa; Curdin Brugger; Sunisa Chaiklieng; Shala Chetty-Mhlanga; Grace A. Chitra; Venugopal Dhananjayan; Afure Ejomah; Christian Ebere Enyoh; Yamdeu Joseph Hubert Galani; Jonathan N. Hogarh; Janefrances N. Ihedioha; Jeanne Priscille Ingabire; Ellinor Isgren; Yêyinou Laura Estelle Loko; Liana Maree; Nkoum Metou’ou Ernest; Haruna Musa Moda; Edward Mubiru; Mwema Felix Mwema; Immaculate Ndagire; Godwin O. Olutona; Peter Otieno; Jordan M. Paguirigan; Reginald Quansah; Charles Ssemugabo; Seruwo Solomon; Mosudi B. Sosan; Mohammad Bashir Sulaiman; Berhan M. Teklu; Isioma Tongo; Osariyekemwen Uyi; Henry Cueva-Vásquez; Adriana Veludo; Paola Viglietti; Mohamed Aqiel Dalvie;Despite the fact that several cases of unsafe pesticide use among farmers in different parts of Africa have been documented, there is limited evidence regarding which specific interventions are effective in reducing pesticide exposure and associated risks to human health and ecology. The overall goal of the African Pesticide Intervention Project (APsent) study is to better understand ongoing research and public health activities related to interventions in Africa through the implementation of suitable target-specific situations or use contexts. A systematic review of the scientific literature on pesticide intervention studies with a focus on Africa was conducted. This was followed by a qualitative survey among stakeholders involved in pesticide research or management in the African region to learn about barriers to and promoters of successful interventions. The project was concluded with an international workshop in November 2021, where a broad range of topics relevant to occupational and environmental health risks were discussed such as acute poisoning, street pesticides, switching to alternatives, or disposal of empty pesticide containers. Key areas of improvement identified were training on pesticide usage techniques, research on the effectiveness of interventions targeted at exposure reduction and/or behavioral changes, awareness raising, implementation of adequate policies, and enforcement of regulations and processes.
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2022Data sources: Europe PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2022Data sources: University of Southern Denmark Research OutputInternational Journal of Environmental Research and Public HealthArticle . 2022 . Peer-reviewedLicense: CC BYData sources: CrossrefeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph19158973&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2022Data sources: Europe PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2022Data sources: University of Southern Denmark Research OutputInternational Journal of Environmental Research and Public HealthArticle . 2022 . Peer-reviewedLicense: CC BYData sources: CrossrefeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph19158973&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 United KingdomPublisher:Elsevier BV Funded by:NIH | Molecular Virology Core, NIH | Making an early diagnosis...NIH| Molecular Virology Core ,NIH| Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast AsiaShanti Narayanasamy; Vu Quoc Dat; Nguyen Tat Thanh; Vo Trieu Ly; Jasper Fuk-Woo Chan; Kwok-Yung Yuen; Chuanyi Ning; Hao Liang; Linghua Li; Anuradha Chowdhary; Sirida Youngchim; Khuanchai Supparatpinyo; Ne Myo Aung; Josh Hanson; Alex Andrianopoulos; John Dougherty; Nelesh P. Govender; David W. Denning; Tom Chiller; Guy E. Thwaites; H. Rogier van Doorn; John R. Perfect; Thuy Le;Summary Talaromycosis (penicilliosis) is an invasive mycosis that is endemic in tropical and subtropical Asia. Talaromycosis primarily affects individuals with advanced HIV disease and other immunosuppressive conditions, and the disease disproportionally affects people in low-income and middle-income countries, particularly agricultural workers in rural areas during their most economically productive years. Approximately 17 300 talaromycosis cases and 4900 associated deaths occur annually. Talaromycosis is highly associated with the tropical monsoon season, when flooding and cyclones can exacerbate the poverty-inducing potential of the disease. Talaromycosis can present as localised or disseminated disease, the latter causing cutaneous lesions that are disfiguring and stigmatising. Despite up to a third of diagnosed cases resulting in death, talaromycosis has received little attention and investment from regional and global funders, policy makers, researchers, and industry. Diagnostic and treatment modalities remain extremely insufficient, however control of talaromycosis is feasible with known public health strategies. This Viewpoint is a global call for talaromycosis to be recognised as a neglected tropical disease to alleviate its impact on susceptible populations.
DOAJ-Articles arrow_drop_down Oxford University Research Archive; The Lancet Global HealthReview . Article . 2021 . 2022 . Peer-reviewedLicense: CC BYThe University of Manchester - Institutional RepositoryArticle . 2021Data sources: The University of Manchester - Institutional Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s2214-109x(21)00350-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 2visibility views 2 download downloads 1 Powered bymore_vert DOAJ-Articles arrow_drop_down Oxford University Research Archive; The Lancet Global HealthReview . Article . 2021 . 2022 . Peer-reviewedLicense: CC BYThe University of Manchester - Institutional RepositoryArticle . 2021Data sources: The University of Manchester - Institutional Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s2214-109x(21)00350-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United KingdomPublisher:Public Library of Science (PLoS) Funded by:NIH | Investigating Febrile Dea..., NIH | The Impact and Society Ec..., UKRI | Zoonoses and Emerging Liv...NIH| Investigating Febrile Deaths in Tanzania (INDITe) ,NIH| The Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: Under ,UKRI| Zoonoses and Emerging Livestock Systems ZELS Reducing the risk to livestock and people programme Associated Studentships ZELS-ASRebecca F. Bodenham; Stella Mazeri; Sarah Cleaveland; John A. Crump; Folorunso Oludayo Fasina; William A. de Glanville; Daniel T. Haydon; Rudovick Kazwala; Tito Kibona; Venance P. Maro; Michael J. Maze; Blandina T. Mmbaga; Niwael Mtui-Malamsha; Gabriel M. Shirima; Emanuel S. Swai; Kate M. Thomas; Barend M. deC. Bronsvoort; Jo E. B. Halliday;pmc: PMC8384210
pmid: 34428205
Background Brucellosis is a neglected zoonosis endemic in many countries, including regions of sub-Saharan Africa. Evaluated diagnostic tools for the detection of exposure to Brucella spp. are important for disease surveillance and guiding prevention and control activities. Methods and findings Bayesian latent class analysis was used to evaluate performance of the Rose Bengal plate test (RBT) and a competitive ELISA (cELISA) in detecting Brucella spp. exposure at the individual animal-level for cattle, sheep, and goats in Tanzania. Median posterior estimates of RBT sensitivity were: 0.779 (95% Bayesian credibility interval (BCI): 0.570–0.894), 0.893 (0.636–0.989), and 0.807 (0.575–0.966), and for cELISA were: 0.623 (0.443–0.790), 0.409 (0.241–0.644), and 0.561 (0.376–0.713), for cattle, sheep, and goats, respectively. Sensitivity BCIs were wide, with the widest for cELISA in sheep. RBT and cELISA median posterior estimates of specificity were high across species models: RBT ranged between 0.989 (0.980–0.998) and 0.995 (0.985–0.999), and cELISA between 0.984 (0.974–0.995) and 0.996 (0.988–1). Each species model generated seroprevalence estimates for two livestock subpopulations, pastoralist and non-pastoralist. Pastoralist seroprevalence estimates were: 0.063 (0.045–0.090), 0.033 (0.018–0.049), and 0.051 (0.034–0.076), for cattle, sheep, and goats, respectively. Non-pastoralist seroprevalence estimates were below 0.01 for all species models. Series and parallel diagnostic approaches were evaluated. Parallel outperformed a series approach. Median posterior estimates for parallel testing were ≥0.920 (0.760–0.986) for sensitivity and ≥0.973 (0.955–0.992) for specificity, for all species models. Conclusions Our findings indicate that Brucella spp. surveillance in Tanzania using RBT and cELISA in parallel at the animal-level would give high test performance. There is a need to evaluate strategies for implementing parallel testing at the herd- and flock-level. Our findings can assist in generating robust Brucella spp. exposure estimates for livestock in Tanzania and wider sub-Saharan Africa. The adoption of locally evaluated robust diagnostic tests in setting-specific surveillance is an important step towards brucellosis prevention and control. Author summary Brucellosis is a zoonotic disease of global importance. The performance of diagnostic tests is variable in different epidemiological settings. Therefore, estimating the setting-specific performance of diagnostic tests for Brucella spp. exposure is important in generating robust surveillance data. The performance of the Rose Bengal plate test (RBT) and a competitive ELISA (cELISA) in detecting Brucella spp. exposure at the individual animal-level for cattle, sheep, and goats from Tanzania was estimated. The RBT and cELISA median estimates for specificity were consistently high, whereas median estimates for sensitivity were more variable between tests and across livestock species. A parallel diagnostic testing approach (i.e., testing all animals by both RBT and cELISA, where a sample positive by either test was considered a parallel positive) gave the best overall test performance, as compared to a series approach (i.e., testing all animals by RBT, with RBT positive animals confirmed by cELISA, where a sample positive for both RBT and cELISA was considered a series positive). There is a need to further investigate strategies for implementing parallel testing at the herd- and flock-level. Our findings can assist in generating robust estimates for Brucella spp. exposure for livestock in Tanzania and similar settings in sub-Saharan Africa. The adoption of locally evaluated robust diagnostic tests in surveillance is an important step towards the prevention and control of brucellosis.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8384210Data sources: PubMed CentralPLoS Neglected Tropical DiseasesArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pntd.0009630&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!download 20download downloads 20 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8384210Data sources: PubMed CentralPLoS Neglected Tropical DiseasesArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pntd.0009630&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Belgium, United StatesPublisher:Public Library of Science (PLoS) Funded by:NIH | PRIMARY HIV PREVENTION IN...NIH| PRIMARY HIV PREVENTION IN PREGNANT AND LACTATING UGANDAN WOMEN:A RANDOMIZED TRIALJoseph Rujumba; Jaco Homsy; Femke Bannink Mbazzi; Zikulah Namukwaya; Alexander Amone; Gordon Rukundo; Elly Katabira; Josaphat Byamugisha; Mary Glenn Fowler; Rachel King;Background HIV status awareness is critical for HIV prevention and care but HIV testing rates remain low in Uganda, especially among men. One suggested approach to increase access and utilisation of HIV testing services is HIV self-testing. We explored perceptions of pregnant and lactating women and their male partners who attended antenatal care, and health care providers in a government hospital in Kampala, Uganda, about HIV self-testing for initial or repeat testing for women and their partners during pregnancy and postpartum We draw implications for scaling-up this new testing approach in Uganda. Methods This was a qualitative study conducted at Mulago National Referral Hospital, Kampala, Uganda, between April and December 2017. We conducted in-depth interviews with five pregnant or lactating women and their five male partners; five focus group discussions (two with women, two with health workers and one with male partners of women attending antenatal care) and five key informant interviews with health workers providing prevention of mother-to-child HIV transmission (PMTCT) services. Data were analysed using content thematic approach. Results There was limited awareness about HIV self-testing especially among pregnant or lactating women and their male partners. Study participants mentioned that HIV self-testing would enable people to know their HIV status faster, they thought the approach would be cost- and time-saving compared to health facility-based HIV testing, improve confidentiality and reduce stigma for those who test HIV positive. They expressed however, a general fear that HIV self-testing would lead to harm to self and others in case one tested HIV positive, including suicide, violence among couples, intentional transmission of HIV, and limited linkage to care due to lack of counselling. The likely misinterpretation of HIV test results especially among those with no or limited education, and possible coercion exerted by male partners on their wives were other potential concerns raised about the use of HIV self-testing. Conclusions There was limited knowledge about HIV self-testing among pregnant and lactating women, their partners and health workers. While the self-testing modality was perceived to be critical for helping people, especially those in casual and distant relationships, to know their HIV status and that of their partners, most study participants believed that HIV self-testing could potentially result in a multitude of negative outcomes in the absence of pre- and post-test counselling. Successful scale-up and integration of self-testing in HIV programs requires community education, provision of information materials and making self-test kits accessible and affordable, especially in rural areas.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8241041Data sources: PubMed CentralGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyeScholarship - University of CaliforniaArticle . 2021Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0253616&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 2visibility views 2 download downloads 3 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8241041Data sources: PubMed CentralGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyeScholarship - University of CaliforniaArticle . 2021Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0253616&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 United KingdomPublisher:Informa UK Limited Funded by:NIH | Maximizing combination HI..., WT | Africa Centre for Health ..., EC | MNSIRSES +1 projectsNIH| Maximizing combination HIV prevention, uptake and retention by adolescent girls and young women ,WT| Africa Centre for Health and Population Studies: Core Support ,EC| MNSIRSES ,WT| Using social networks to understand and intervene on HIV epidemic spreadNatsayi Chimbindi; Nondumiso Mthiyane; Thembelihle Zuma; Kathy Baisley; Deenan Pillay; Nuala McGrath; Guy Harling; Lorraine Sherr; Isolde Birdthistle; Sian Floyd; Jaco Dreyer; Sarah Nakasone; Janet Seeley; Maryam Shahmanesh;Pre-Exposure Prophylaxis (PrEP) is a potential game-changer for HIV. We used PrEP introduction for Young Women Who Sell Sex (YSSW) in a rural South Africa district to understand community norms and PrEP coverage in YSSW. Between 2017–2018 we measured eligibility, awareness and uptake of PrEP in a representative cohort of 2184 Adolescent Girls and Young Women (AGYW) aged 13–22. We conducted group discussions with young people and community members (19); key informant interviews (9), in-depth interviews with 15–24 year-olds (58) and providers (33). All interviews were analysed using thematic analysis. PrEP awareness increased from 2% to 9%. Among 965 AGYW sexually-active by 2018, 13.4% (95%CI: 11.4–15.7%) reported transactional sex and 10.6% (95%CI: 8.8–12.7%) sex for money. Of the 194 YWSS, 21 were aware of PrEP, but none had used it. Youth were enthusiastic about PrEP as tool for HIV prevention; whilst older community members were cautious about a technology they had limited experience with but could benefit select groups. Teachers and healthcare providers were concerned that PrEP would lower personal responsibility for sexual health. In conclusion, the narrow and limited introduction of PrEP to YWSS reduced the accessibility and reach. Introducing PrEP as part of sexual health care may improve demand and access for YWSS.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/09540121.2021.1902933&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 29visibility views 29 download downloads 33 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/09540121.2021.1902933&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 United KingdomPublisher:Public Library of Science (PLoS) Funded by:NIH | Quantifying Spatial Repre...NIH| Quantifying Spatial Representativeness and Uncertainty in Antenatal Care Sentinel Surveillance for HIV in Sub-Saharan Africa.Authors: Leigh F. Johnson; Mmamapudi Kubjane; Jeffrey W. Eaton;Leigh F. Johnson; Mmamapudi Kubjane; Jeffrey W. Eaton;Background HIV prevalence data among pregnant women have been critical to estimating HIV trends and geographical patterns of HIV in many African countries. Although antenatal HIV prevalence data are known to be biased representations of HIV prevalence in the general population, mathematical models have made various adjustments to control for known sources of bias, including the effect of HIV on fertility, the age profile of pregnant women and sexual experience. Methods and findings We assessed whether assumptions about antenatal bias affect conclusions about trends and geographical variation in HIV prevalence, using simulated datasets generated by an agent-based model of HIV and fertility in South Africa. Results suggest that even when controlling for age and other previously-considered sources of bias, antenatal bias in South Africa has not been constant over time, and trends in bias differ substantially by age. Differences in the average duration of infection explain much of this variation. We propose an HIV duration-adjusted measure of antenatal bias that is more stable, which yields higher estimates of HIV incidence in recent years and at older ages. Simpler measures of antenatal bias, which are not age-adjusted, yield estimates of HIV prevalence and incidence that are too high in the early stages of the HIV epidemic, and that are less precise. Antenatal bias in South Africa is substantially greater in urban areas than in rural areas. Conclusions Age-standardized approaches to defining antenatal bias are likely to improve precision in model-based estimates, and further recency adjustments increase estimates of HIV incidence in recent years and at older ages. Incompletely adjusting for changing antenatal bias may explain why previous model estimates overstated the early HIV burden in South Africa. New assays to estimate the fraction of HIV-positive pregnant women who are recently infected could play an important role in better estimating antenatal bias.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7679018Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2020License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1371/journal.pone.0242595&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 1visibility views 1 download downloads 4 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7679018Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2020License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Research , Other literature type 2020 United KingdomPublisher:Cold Spring Harbor Laboratory Funded by:NIH | Studies of Mucosal Associ..., WT | Using social networks to ..., NIH | Quantification of pattern... +1 projectsNIH| Studies of Mucosal Associated Invariant T (MAIT) cells in people with HIV, TB and HIV/TB co-infection in South Africa ,WT| Using social networks to understand and intervene on HIV epidemic spread ,NIH| Quantification of patterns of multimorbidity to develop effective and efficient models of HIV, TB and NCD co-care in rural South Africa ,WT| Africa Health Research Institute (GBP record)Guy Harling; Francesc Xavier Gómez-Olivé; Joseph Tlouyamma; Tinofa Mutevedzi; Chodziwadziwa W. Kabudula; Ruth Mahlako; Urisha Singh; Daniel Ohene-Kwofie; Rose Buckland; Pedzisai Ndagurwa; Dickman Gareta; Resign Gunda; Thobeka Mngomezulu; Siyabonga Nxumalo; Emily B. Wong; Kathleen Kahn; Mark J. Siedner; Eric Maimela; Stephen Tollman; Mark A. Collinson; Kobus Herbst;pmc: PMC8121138 , PMC7668759
BACKGROUND In March 2020, South Africa implemented strict nonpharmaceutical interventions (NPIs) to contain the spread of COVID-19. Over the subsequent 5 months, NPI policies were eased in stages according to a national strategy. COVID-19 spread throughout the country heterogeneously; the disease reached rural areas by July and case numbers peaked from July to August. A second COVID-19 wave began in late 2020. Data on the impact of NPI policies on social and economic well-being and access to health care are limited. OBJECTIVE We aimed to determine how rural residents in three South African provinces changed their behaviors during the first COVID-19 epidemic wave. METHODS The South African Population Research Infrastructure Network nodes in the Mpumalanga (Agincourt), KwaZulu-Natal, (Africa Health Research Institute) and Limpopo (Dikgale-Mamabolo-Mothiba) provinces conducted up to 14 rounds of longitudinal telephone surveys among randomly sampled households from rural and periurban surveillance populations every 2-3 weeks. Interviews included questions on the following topics: COVID-19–related knowledge and behaviors, the health and economic impacts of NPIs, and mental health. We analyzed how responses varied based on NPI stringency and household sociodemographics. RESULTS In total, 5120 households completed 23,095 interviews between April and December 2020. Respondents’ self-reported satisfaction with their COVID-19–related knowledge and face mask use rapidly rose to 85% and 95%, respectively, by August. As selected NPIs were eased, the amount of travel increased, economic losses were reduced, and the prevalence of anxiety and depression symptoms fell. When the number of COVID-19 cases spiked at one node in July, the amount of travel dropped rapidly and the rate of missed daily medications doubled. Households where more adults received government-funded old-age pensions reported concerns about economic matters and medication access less often. CONCLUSIONS South Africans complied with stringent, COVID-19–related NPIs despite the threat of substantial social, economic, and health repercussions. Government-supported social welfare programs appeared to buffer interruptions in income and health care access during local outbreaks. Epidemic control policies must be balanced against the broader well-being of people in resource-limited settings and designed with parallel support systems when such policies threaten peoples’ income and access to basic services.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8121138Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7668759Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8121138Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7668759Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2020 United StatesPublisher:Cold Spring Harbor Laboratory Funded by:NIH | Population Biology of Afr..., NIH | Ecology of African Highla...NIH| Population Biology of African Malaria Vectors and Parasites ,NIH| Ecology of African Highland MalariaOwuor, Kevin O; Machani, Maxwell G; Mukabana, Wolfgang R; Munga, Stephen O; Yan, Guiyun; Ochomo, Eric; Afrane, Yaw A;Background Long Lasting Insecticidal Nets (LLINs) and indoor residual spraying (IRS) represent powerful tools for controlling malaria vectors in sub-Saharan Africa. The success of these interventions relies on their capability to inhibit indoor feeding and resting of malaria mosquitoes. This study sought to understand the interaction of insecticide resistance with indoor and outdoor resting behavioral responses of malaria vectors from Western Kenya. Methods The status of insecticide resistance among indoor and outdoor resting anopheline mosquitoes was compared in Anopheles mosquitoes collected from Kisumu and Bungoma counties in Western Kenya. The level and intensity of resistance were measured using WHO-tube and CDC-bottle bioassays, respectively. The synergist piperonyl butoxide (PBO) was used to determine if metabolic activity (monooxygenase enzymes) explained the resistance observed. The mutations at the voltage-gated sodium channel (Vgsc) gene and Ace 1 gene were characterized using PCR methods. Microplate assays were used to measure levels of detoxification enzymes if present. Results A total of 1094 samples were discriminated within Anopheles gambiae s.l. and 289 within An. funestus s.l. In Kisian (Kisumu county), the dominant species was Anopheles arabiensis 75.2% (391/520) while in Kimaeti (Bungoma county) collections the dominant sibling species was Anopheles gambiae s.s 96.5% (554/574). The An. funestus s.l samples analysed were all An. funestus s.s from both sites. Pyrethroid resistance of An.gambiae s.l F1 progeny was observed in all sites. Lower mortality was observed against deltamethrin for the progeny of indoor resting mosquitoes compared to outdoor resting mosquitoes (Mortality rate: 37% vs 51%, P = 0.044). The intensity assays showed moderate-intensity resistance to deltamethrin in the progeny of mosquitoes collected from indoors and outdoors in both study sites. In Kisian, the frequency of vgsc-L1014S and vgsc-L1014F mutation was 0.14 and 0.19 respectively in indoor resting malaria mosquitoes while those of the outdoor resting mosquitoes were 0.12 and 0.12 respectively. The ace 1 mutation was present in higher frequency in the F1 of mosquitoes resting indoors (0.23) compared to those of mosquitoes resting outdoors (0.12). In Kimaeti, the frequencies of vgsc-L1014S and vgsc-L1014F were 0.75 and 0.05 respectively for the F1 of mosquitoes collected indoors whereas those of outdoor resting ones were 0.67 and 0.03 respectively. The ace 1 G119S mutation was present in progeny of mosquitoes from Kimaeti resting indoors (0.05) whereas it was absent in those resting outdoors. Monooxygenase activity was elevated by 1.83 folds in Kisian and by 1.33 folds in Kimaeti for mosquitoes resting indoors than those resting outdoors respectively. Conclusion The study recorded high phenotypic, metabolic and genotypic insecticide resistance in indoor resting populations of malaria vectors compared to their outdoor resting counterparts. The indication of moderate resistance intensity for the indoor resting mosquitoes is alarming as it could have an operational impact on the efficacy of the existing pyrethroid based vector control tools. The use of synergist (PBO) in LLINs may be a better alternative for widespread use in these regions recording high insecticide resistance.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7920366Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2021Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7920366Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2021Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 United KingdomPublisher:Springer Science and Business Media LLC Funded by:WT, NIH | Maximizing combination HI..., WT | Africa Centre for Health ... +1 projectsWT ,NIH| Maximizing combination HIV prevention, uptake and retention by adolescent girls and young women ,WT| Africa Centre for Health and Population Studies: Core Support ,EC| MNSIRSESNakasone, Sarah E; Chimbindi, Natsayi; Mthiyane, Nondumiso; Nkosi, Busisiwe; Zuma, Thembelihle; Baisley, Kathy; Dreyer, Jaco; Pillay, Deenan; Floyd, Sian; Birdthistle, Isolde; Seeley, Janet; Shahmanesh, Maryam;AbstractIntroductionAdolescent girls and young women (AGYW) remain disproportionately affected by HIV. In a rural area of South Africa with an annual incidence (2011–2015) of 5 and 7% per annum for 15–19 and 20–24-year olds respectively, oral pre-exposure prophylaxis (PrEP) could provide AGYW with a form of HIV prevention they can more easily control. Using quantitative and qualitative methods, we describe findings from a study conducted in 2017 that assessed knowledge of and attitudes toward PrEP to better understand community readiness for an AGYW PrEP rollout.MethodsWe used descriptive analysis of a quantitative demographic survey (n = 8,414 ages 15–86) to identify population awareness and early PrEP adopters. We also conducted semi-structured, in-depth interviews with a purposive sample of 52 potential PrEP gatekeepers (health care workers, community leaders) to assess their potential influence in an AGYW PrEP rollout and describe the current sexual health landscape. Interviews were recorded, transcribed, and iteratively coded to identify major themes.ResultsPrEP knowledge in the general population, measured through a demographic survey, was low (n = 125/8,414, 1.49% had heard of the drug). Medicalized delivery pathways created hostility to AGYW PrEP use. Key informants had higher levels of knowledge about PrEP and saw it as a needed intervention. Community norms around adolescent sexuality, which painted sexually active youth as irresponsible and disengaged from their own health, made many ambivalent towards a PrEP rollout to AGYW. Health care workers discussed ways to shame AGYW if they tried to access PrEP as they feared the drug would encourage promiscuity and “risky” behaviour. Others interviewed opposed provision on the basis of health care equity and feared PrEP would divert both drug and human resources from treatment programs.ConclusionsThe health system in this poor, high-HIV incidence area had multiple barriers to a PrEP rollout to AGYW. Norms around adolescent sexuality and gatekeeper concerns that PrEP could divert health resources from treatment to prevention could create barriers to PrEP roll-out in this setting. Alternate modes of delivery, particularly those which are youth-led and demedicalize PrEP, must be explored.
CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7487548Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 222visibility views 222 download downloads 18 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7487548Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2023Publisher:Universidad Autonoma de Yucatan. Facultad de Medicina Veterinaria y Zootecnia Funded by:NIH | CTSA Institutional Mentor...NIH| CTSA Institutional Mentored Career Development Program (KL2)Authors: Faduma Abdullahi Abdirahman; Raphael Githaiga Wahome; Catherine Kaluwa; Jemimah Oduma; +6 AuthorsFaduma Abdullahi Abdirahman; Raphael Githaiga Wahome; Catherine Kaluwa; Jemimah Oduma; Jynette Jynette Nkatha; Angella Adhiambo; Kitoga Byalungwa Kyotos; Brigitte Bagnol; Marieke Rosenbaum; Janetrix Hellen Amuguni;doi: 10.56369/tsaes.3915
<p><strong>Background.</strong> Traditionally, poultry is kept and reared by women in extensive production systems. In Kenya and most developing countries, smallholder poultry productivity is constrained by diseases such as Newcastle disease (ND), which is preventable via a vaccine, yet contributes to significant morbidity and mortality among flocks primarily owned and managed by women in villages. <strong>Objective.</strong> This study aimed to map the Newcastle disease vaccine value chain stakeholders and identify the barriers and opportunities for women's engagement along the Newcastle disease vaccine value chain. <strong>Methodology</strong>. Qualitative data were collected with 15 key informant interviews and four focus group discussions with a total of 42 poultry farmers in Machakos Town sub-county, Kenya. <strong>Results.</strong> The majority of the vaccine value chain consumers were women, and limited information was one of the root causes for not vaccinating their chickens. Vaccines were considered expensive and difficult to access as the production areas were remote from the agrovet shops that retail vaccines. <strong>Implication.</strong> The study showed that women farmers had no financial control to enable vaccine procurement. <strong>Conclusion</strong>. Based on the results the government using the Extension service providers should train smallholder farmers on how to use the ND vaccine. Furthermore, manufacturers of thermo-stable ND vaccines should furnish Agrovet shops with data to enable its adoption in remote areas where the cold chain is unreliable.<strong></strong></p>
Tropical and Subtrop... arrow_drop_down Tropical and Subtropical AgroecosystemsArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Tropical and Subtrop... arrow_drop_down Tropical and Subtropical AgroecosystemsArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.56369/tsaes.3915&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 Denmark, United States, SwitzerlandPublisher:MDPI AG Funded by:NIH | Vulnerability of the Adol...NIH| Vulnerability of the Adolescent Brain to Organophosphorus PesticidesMartin Röösli; Samuel Fuhrimann; Aggrey Atuhaire; Hanna-Andrea Rother; James Dabrowski; Brenda Eskenazi; Erik Jørs; Paul C. Jepson; Leslie London; Saloshni Naidoo; Diane S. Rohlman; Ivy Saunyama; Berna van Wendel de Joode; Adeoluwa O. Adeleye; Oyebanji O. Alagbo; Dem Aliaj; Jember Azanaw; Ravichandran Beerappa; Curdin Brugger; Sunisa Chaiklieng; Shala Chetty-Mhlanga; Grace A. Chitra; Venugopal Dhananjayan; Afure Ejomah; Christian Ebere Enyoh; Yamdeu Joseph Hubert Galani; Jonathan N. Hogarh; Janefrances N. Ihedioha; Jeanne Priscille Ingabire; Ellinor Isgren; Yêyinou Laura Estelle Loko; Liana Maree; Nkoum Metou’ou Ernest; Haruna Musa Moda; Edward Mubiru; Mwema Felix Mwema; Immaculate Ndagire; Godwin O. Olutona; Peter Otieno; Jordan M. Paguirigan; Reginald Quansah; Charles Ssemugabo; Seruwo Solomon; Mosudi B. Sosan; Mohammad Bashir Sulaiman; Berhan M. Teklu; Isioma Tongo; Osariyekemwen Uyi; Henry Cueva-Vásquez; Adriana Veludo; Paola Viglietti; Mohamed Aqiel Dalvie;Despite the fact that several cases of unsafe pesticide use among farmers in different parts of Africa have been documented, there is limited evidence regarding which specific interventions are effective in reducing pesticide exposure and associated risks to human health and ecology. The overall goal of the African Pesticide Intervention Project (APsent) study is to better understand ongoing research and public health activities related to interventions in Africa through the implementation of suitable target-specific situations or use contexts. A systematic review of the scientific literature on pesticide intervention studies with a focus on Africa was conducted. This was followed by a qualitative survey among stakeholders involved in pesticide research or management in the African region to learn about barriers to and promoters of successful interventions. The project was concluded with an international workshop in November 2021, where a broad range of topics relevant to occupational and environmental health risks were discussed such as acute poisoning, street pesticides, switching to alternatives, or disposal of empty pesticide containers. Key areas of improvement identified were training on pesticide usage techniques, research on the effectiveness of interventions targeted at exposure reduction and/or behavioral changes, awareness raising, implementation of adequate policies, and enforcement of regulations and processes.
International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2022Data sources: Europe PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2022Data sources: University of Southern Denmark Research OutputInternational Journal of Environmental Research and Public HealthArticle . 2022 . Peer-reviewedLicense: CC BYData sources: CrossrefeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2022Data sources: Europe PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2022Data sources: University of Southern Denmark Research OutputInternational Journal of Environmental Research and Public HealthArticle . 2022 . Peer-reviewedLicense: CC BYData sources: CrossrefeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph19158973&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 United KingdomPublisher:Elsevier BV Funded by:NIH | Molecular Virology Core, NIH | Making an early diagnosis...NIH| Molecular Virology Core ,NIH| Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast AsiaShanti Narayanasamy; Vu Quoc Dat; Nguyen Tat Thanh; Vo Trieu Ly; Jasper Fuk-Woo Chan; Kwok-Yung Yuen; Chuanyi Ning; Hao Liang; Linghua Li; Anuradha Chowdhary; Sirida Youngchim; Khuanchai Supparatpinyo; Ne Myo Aung; Josh Hanson; Alex Andrianopoulos; John Dougherty; Nelesh P. Govender; David W. Denning; Tom Chiller; Guy E. Thwaites; H. Rogier van Doorn; John R. Perfect; Thuy Le;Summary Talaromycosis (penicilliosis) is an invasive mycosis that is endemic in tropical and subtropical Asia. Talaromycosis primarily affects individuals with advanced HIV disease and other immunosuppressive conditions, and the disease disproportionally affects people in low-income and middle-income countries, particularly agricultural workers in rural areas during their most economically productive years. Approximately 17 300 talaromycosis cases and 4900 associated deaths occur annually. Talaromycosis is highly associated with the tropical monsoon season, when flooding and cyclones can exacerbate the poverty-inducing potential of the disease. Talaromycosis can present as localised or disseminated disease, the latter causing cutaneous lesions that are disfiguring and stigmatising. Despite up to a third of diagnosed cases resulting in death, talaromycosis has received little attention and investment from regional and global funders, policy makers, researchers, and industry. Diagnostic and treatment modalities remain extremely insufficient, however control of talaromycosis is feasible with known public health strategies. This Viewpoint is a global call for talaromycosis to be recognised as a neglected tropical disease to alleviate its impact on susceptible populations.
DOAJ-Articles arrow_drop_down Oxford University Research Archive; The Lancet Global HealthReview . Article . 2021 . 2022 . Peer-reviewedLicense: CC BYThe University of Manchester - Institutional RepositoryArticle . 2021Data sources: The University of Manchester - Institutional Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 2visibility views 2 download downloads 1 Powered bymore_vert DOAJ-Articles arrow_drop_down Oxford University Research Archive; The Lancet Global HealthReview . Article . 2021 . 2022 . Peer-reviewedLicense: CC BYThe University of Manchester - Institutional RepositoryArticle . 2021Data sources: The University of Manchester - Institutional Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 United KingdomPublisher:Public Library of Science (PLoS) Funded by:NIH | Investigating Febrile Dea..., NIH | The Impact and Society Ec..., UKRI | Zoonoses and Emerging Liv...NIH| Investigating Febrile Deaths in Tanzania (INDITe) ,NIH| The Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: Under ,UKRI| Zoonoses and Emerging Livestock Systems ZELS Reducing the risk to livestock and people programme Associated Studentships ZELS-ASRebecca F. Bodenham; Stella Mazeri; Sarah Cleaveland; John A. Crump; Folorunso Oludayo Fasina; William A. de Glanville; Daniel T. Haydon; Rudovick Kazwala; Tito Kibona; Venance P. Maro; Michael J. Maze; Blandina T. Mmbaga; Niwael Mtui-Malamsha; Gabriel M. Shirima; Emanuel S. Swai; Kate M. Thomas; Barend M. deC. Bronsvoort; Jo E. B. Halliday;pmc: PMC8384210
pmid: 34428205
Background Brucellosis is a neglected zoonosis endemic in many countries, including regions of sub-Saharan Africa. Evaluated diagnostic tools for the detection of exposure to Brucella spp. are important for disease surveillance and guiding prevention and control activities. Methods and findings Bayesian latent class analysis was used to evaluate performance of the Rose Bengal plate test (RBT) and a competitive ELISA (cELISA) in detecting Brucella spp. exposure at the individual animal-level for cattle, sheep, and goats in Tanzania. Median posterior estimates of RBT sensitivity were: 0.779 (95% Bayesian credibility interval (BCI): 0.570–0.894), 0.893 (0.636–0.989), and 0.807 (0.575–0.966), and for cELISA were: 0.623 (0.443–0.790), 0.409 (0.241–0.644), and 0.561 (0.376–0.713), for cattle, sheep, and goats, respectively. Sensitivity BCIs were wide, with the widest for cELISA in sheep. RBT and cELISA median posterior estimates of specificity were high across species models: RBT ranged between 0.989 (0.980–0.998) and 0.995 (0.985–0.999), and cELISA between 0.984 (0.974–0.995) and 0.996 (0.988–1). Each species model generated seroprevalence estimates for two livestock subpopulations, pastoralist and non-pastoralist. Pastoralist seroprevalence estimates were: 0.063 (0.045–0.090), 0.033 (0.018–0.049), and 0.051 (0.034–0.076), for cattle, sheep, and goats, respectively. Non-pastoralist seroprevalence estimates were below 0.01 for all species models. Series and parallel diagnostic approaches were evaluated. Parallel outperformed a series approach. Median posterior estimates for parallel testing were ≥0.920 (0.760–0.986) for sensitivity and ≥0.973 (0.955–0.992) for specificity, for all species models. Conclusions Our findings indicate that Brucella spp. surveillance in Tanzania using RBT and cELISA in parallel at the animal-level would give high test performance. There is a need to evaluate strategies for implementing parallel testing at the herd- and flock-level. Our findings can assist in generating robust Brucella spp. exposure estimates for livestock in Tanzania and wider sub-Saharan Africa. The adoption of locally evaluated robust diagnostic tests in setting-specific surveillance is an important step towards brucellosis prevention and control. Author summary Brucellosis is a zoonotic disease of global importance. The performance of diagnostic tests is variable in different epidemiological settings. Therefore, estimating the setting-specific performance of diagnostic tests for Brucella spp. exposure is important in generating robust surveillance data. The performance of the Rose Bengal plate test (RBT) and a competitive ELISA (cELISA) in detecting Brucella spp. exposure at the individual animal-level for cattle, sheep, and goats from Tanzania was estimated. The RBT and cELISA median estimates for specificity were consistently high, whereas median estimates for sensitivity were more variable between tests and across livestock species. A parallel diagnostic testing approach (i.e., testing all animals by both RBT and cELISA, where a sample positive by either test was considered a parallel positive) gave the best overall test performance, as compared to a series approach (i.e., testing all animals by RBT, with RBT positive animals confirmed by cELISA, where a sample positive for both RBT and cELISA was considered a series positive). There is a need to further investigate strategies for implementing parallel testing at the herd- and flock-level. Our findings can assist in generating robust estimates for Brucella spp. exposure for livestock in Tanzania and similar settings in sub-Saharan Africa. The adoption of locally evaluated robust diagnostic tests in surveillance is an important step towards the prevention and control of brucellosis.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8384210Data sources: PubMed CentralPLoS Neglected Tropical DiseasesArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!download 20download downloads 20 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8384210Data sources: PubMed CentralPLoS Neglected Tropical DiseasesArticle . 2021 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Belgium, United StatesPublisher:Public Library of Science (PLoS) Funded by:NIH | PRIMARY HIV PREVENTION IN...NIH| PRIMARY HIV PREVENTION IN PREGNANT AND LACTATING UGANDAN WOMEN:A RANDOMIZED TRIALJoseph Rujumba; Jaco Homsy; Femke Bannink Mbazzi; Zikulah Namukwaya; Alexander Amone; Gordon Rukundo; Elly Katabira; Josaphat Byamugisha; Mary Glenn Fowler; Rachel King;Background HIV status awareness is critical for HIV prevention and care but HIV testing rates remain low in Uganda, especially among men. One suggested approach to increase access and utilisation of HIV testing services is HIV self-testing. We explored perceptions of pregnant and lactating women and their male partners who attended antenatal care, and health care providers in a government hospital in Kampala, Uganda, about HIV self-testing for initial or repeat testing for women and their partners during pregnancy and postpartum We draw implications for scaling-up this new testing approach in Uganda. Methods This was a qualitative study conducted at Mulago National Referral Hospital, Kampala, Uganda, between April and December 2017. We conducted in-depth interviews with five pregnant or lactating women and their five male partners; five focus group discussions (two with women, two with health workers and one with male partners of women attending antenatal care) and five key informant interviews with health workers providing prevention of mother-to-child HIV transmission (PMTCT) services. Data were analysed using content thematic approach. Results There was limited awareness about HIV self-testing especially among pregnant or lactating women and their male partners. Study participants mentioned that HIV self-testing would enable people to know their HIV status faster, they thought the approach would be cost- and time-saving compared to health facility-based HIV testing, improve confidentiality and reduce stigma for those who test HIV positive. They expressed however, a general fear that HIV self-testing would lead to harm to self and others in case one tested HIV positive, including suicide, violence among couples, intentional transmission of HIV, and limited linkage to care due to lack of counselling. The likely misinterpretation of HIV test results especially among those with no or limited education, and possible coercion exerted by male partners on their wives were other potential concerns raised about the use of HIV self-testing. Conclusions There was limited knowledge about HIV self-testing among pregnant and lactating women, their partners and health workers. While the self-testing modality was perceived to be critical for helping people, especially those in casual and distant relationships, to know their HIV status and that of their partners, most study participants believed that HIV self-testing could potentially result in a multitude of negative outcomes in the absence of pre- and post-test counselling. Successful scale-up and integration of self-testing in HIV programs requires community education, provision of information materials and making self-test kits accessible and affordable, especially in rural areas.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8241041Data sources: PubMed CentralGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyeScholarship - University of CaliforniaArticle . 2021Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 2visibility views 2 download downloads 3 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8241041Data sources: PubMed CentralGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyeScholarship - University of CaliforniaArticle . 2021Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 United KingdomPublisher:Informa UK Limited Funded by:NIH | Maximizing combination HI..., WT | Africa Centre for Health ..., EC | MNSIRSES +1 projectsNIH| Maximizing combination HIV prevention, uptake and retention by adolescent girls and young women ,WT| Africa Centre for Health and Population Studies: Core Support ,EC| MNSIRSES ,WT| Using social networks to understand and intervene on HIV epidemic spreadNatsayi Chimbindi; Nondumiso Mthiyane; Thembelihle Zuma; Kathy Baisley; Deenan Pillay; Nuala McGrath; Guy Harling; Lorraine Sherr; Isolde Birdthistle; Sian Floyd; Jaco Dreyer; Sarah Nakasone; Janet Seeley; Maryam Shahmanesh;Pre-Exposure Prophylaxis (PrEP) is a potential game-changer for HIV. We used PrEP introduction for Young Women Who Sell Sex (YSSW) in a rural South Africa district to understand community norms and PrEP coverage in YSSW. Between 2017–2018 we measured eligibility, awareness and uptake of PrEP in a representative cohort of 2184 Adolescent Girls and Young Women (AGYW) aged 13–22. We conducted group discussions with young people and community members (19); key informant interviews (9), in-depth interviews with 15–24 year-olds (58) and providers (33). All interviews were analysed using thematic analysis. PrEP awareness increased from 2% to 9%. Among 965 AGYW sexually-active by 2018, 13.4% (95%CI: 11.4–15.7%) reported transactional sex and 10.6% (95%CI: 8.8–12.7%) sex for money. Of the 194 YWSS, 21 were aware of PrEP, but none had used it. Youth were enthusiastic about PrEP as tool for HIV prevention; whilst older community members were cautious about a technology they had limited experience with but could benefit select groups. Teachers and healthcare providers were concerned that PrEP would lower personal responsibility for sexual health. In conclusion, the narrow and limited introduction of PrEP to YWSS reduced the accessibility and reach. Introducing PrEP as part of sexual health care may improve demand and access for YWSS.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 29visibility views 29 download downloads 33 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 United KingdomPublisher:Public Library of Science (PLoS) Funded by:NIH | Quantifying Spatial Repre...NIH| Quantifying Spatial Representativeness and Uncertainty in Antenatal Care Sentinel Surveillance for HIV in Sub-Saharan Africa.Authors: Leigh F. Johnson; Mmamapudi Kubjane; Jeffrey W. Eaton;Leigh F. Johnson; Mmamapudi Kubjane; Jeffrey W. Eaton;Background HIV prevalence data among pregnant women have been critical to estimating HIV trends and geographical patterns of HIV in many African countries. Although antenatal HIV prevalence data are known to be biased representations of HIV prevalence in the general population, mathematical models have made various adjustments to control for known sources of bias, including the effect of HIV on fertility, the age profile of pregnant women and sexual experience. Methods and findings We assessed whether assumptions about antenatal bias affect conclusions about trends and geographical variation in HIV prevalence, using simulated datasets generated by an agent-based model of HIV and fertility in South Africa. Results suggest that even when controlling for age and other previously-considered sources of bias, antenatal bias in South Africa has not been constant over time, and trends in bias differ substantially by age. Differences in the average duration of infection explain much of this variation. We propose an HIV duration-adjusted measure of antenatal bias that is more stable, which yields higher estimates of HIV incidence in recent years and at older ages. Simpler measures of antenatal bias, which are not age-adjusted, yield estimates of HIV prevalence and incidence that are too high in the early stages of the HIV epidemic, and that are less precise. Antenatal bias in South Africa is substantially greater in urban areas than in rural areas. Conclusions Age-standardized approaches to defining antenatal bias are likely to improve precision in model-based estimates, and further recency adjustments increase estimates of HIV incidence in recent years and at older ages. Incompletely adjusting for changing antenatal bias may explain why previous model estimates overstated the early HIV burden in South Africa. New assays to estimate the fraction of HIV-positive pregnant women who are recently infected could play an important role in better estimating antenatal bias.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7679018Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2020License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 1visibility views 1 download downloads 4 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7679018Data sources: PubMed CentralSpiral - Imperial College Digital RepositoryArticle . 2020License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Research , Other literature type 2020 United KingdomPublisher:Cold Spring Harbor Laboratory Funded by:NIH | Studies of Mucosal Associ..., WT | Using social networks to ..., NIH | Quantification of pattern... +1 projectsNIH| Studies of Mucosal Associated Invariant T (MAIT) cells in people with HIV, TB and HIV/TB co-infection in South Africa ,WT| Using social networks to understand and intervene on HIV epidemic spread ,NIH| Quantification of patterns of multimorbidity to develop effective and efficient models of HIV, TB and NCD co-care in rural South Africa ,WT| Africa Health Research Institute (GBP record)Guy Harling; Francesc Xavier Gómez-Olivé; Joseph Tlouyamma; Tinofa Mutevedzi; Chodziwadziwa W. Kabudula; Ruth Mahlako; Urisha Singh; Daniel Ohene-Kwofie; Rose Buckland; Pedzisai Ndagurwa; Dickman Gareta; Resign Gunda; Thobeka Mngomezulu; Siyabonga Nxumalo; Emily B. Wong; Kathleen Kahn; Mark J. Siedner; Eric Maimela; Stephen Tollman; Mark A. Collinson; Kobus Herbst;pmc: PMC8121138 , PMC7668759
BACKGROUND In March 2020, South Africa implemented strict nonpharmaceutical interventions (NPIs) to contain the spread of COVID-19. Over the subsequent 5 months, NPI policies were eased in stages according to a national strategy. COVID-19 spread throughout the country heterogeneously; the disease reached rural areas by July and case numbers peaked from July to August. A second COVID-19 wave began in late 2020. Data on the impact of NPI policies on social and economic well-being and access to health care are limited. OBJECTIVE We aimed to determine how rural residents in three South African provinces changed their behaviors during the first COVID-19 epidemic wave. METHODS The South African Population Research Infrastructure Network nodes in the Mpumalanga (Agincourt), KwaZulu-Natal, (Africa Health Research Institute) and Limpopo (Dikgale-Mamabolo-Mothiba) provinces conducted up to 14 rounds of longitudinal telephone surveys among randomly sampled households from rural and periurban surveillance populations every 2-3 weeks. Interviews included questions on the following topics: COVID-19–related knowledge and behaviors, the health and economic impacts of NPIs, and mental health. We analyzed how responses varied based on NPI stringency and household sociodemographics. RESULTS In total, 5120 households completed 23,095 interviews between April and December 2020. Respondents’ self-reported satisfaction with their COVID-19–related knowledge and face mask use rapidly rose to 85% and 95%, respectively, by August. As selected NPIs were eased, the amount of travel increased, economic losses were reduced, and the prevalence of anxiety and depression symptoms fell. When the number of COVID-19 cases spiked at one node in July, the amount of travel dropped rapidly and the rate of missed daily medications doubled. Households where more adults received government-funded old-age pensions reported concerns about economic matters and medication access less often. CONCLUSIONS South Africans complied with stringent, COVID-19–related NPIs despite the threat of substantial social, economic, and health repercussions. Government-supported social welfare programs appeared to buffer interruptions in income and health care access during local outbreaks. Epidemic control policies must be balanced against the broader well-being of people in resource-limited settings and designed with parallel support systems when such policies threaten peoples’ income and access to basic services.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8121138Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7668759Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8121138Data sources: PubMed CentralEurope PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7668759Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Article 2020 United StatesPublisher:Cold Spring Harbor Laboratory Funded by:NIH | Population Biology of Afr..., NIH | Ecology of African Highla...NIH| Population Biology of African Malaria Vectors and Parasites ,NIH| Ecology of African Highland MalariaOwuor, Kevin O; Machani, Maxwell G; Mukabana, Wolfgang R; Munga, Stephen O; Yan, Guiyun; Ochomo, Eric; Afrane, Yaw A;Background Long Lasting Insecticidal Nets (LLINs) and indoor residual spraying (IRS) represent powerful tools for controlling malaria vectors in sub-Saharan Africa. The success of these interventions relies on their capability to inhibit indoor feeding and resting of malaria mosquitoes. This study sought to understand the interaction of insecticide resistance with indoor and outdoor resting behavioral responses of malaria vectors from Western Kenya. Methods The status of insecticide resistance among indoor and outdoor resting anopheline mosquitoes was compared in Anopheles mosquitoes collected from Kisumu and Bungoma counties in Western Kenya. The level and intensity of resistance were measured using WHO-tube and CDC-bottle bioassays, respectively. The synergist piperonyl butoxide (PBO) was used to determine if metabolic activity (monooxygenase enzymes) explained the resistance observed. The mutations at the voltage-gated sodium channel (Vgsc) gene and Ace 1 gene were characterized using PCR methods. Microplate assays were used to measure levels of detoxification enzymes if present. Results A total of 1094 samples were discriminated within Anopheles gambiae s.l. and 289 within An. funestus s.l. In Kisian (Kisumu county), the dominant species was Anopheles arabiensis 75.2% (391/520) while in Kimaeti (Bungoma county) collections the dominant sibling species was Anopheles gambiae s.s 96.5% (554/574). The An. funestus s.l samples analysed were all An. funestus s.s from both sites. Pyrethroid resistance of An.gambiae s.l F1 progeny was observed in all sites. Lower mortality was observed against deltamethrin for the progeny of indoor resting mosquitoes compared to outdoor resting mosquitoes (Mortality rate: 37% vs 51%, P = 0.044). The intensity assays showed moderate-intensity resistance to deltamethrin in the progeny of mosquitoes collected from indoors and outdoors in both study sites. In Kisian, the frequency of vgsc-L1014S and vgsc-L1014F mutation was 0.14 and 0.19 respectively in indoor resting malaria mosquitoes while those of the outdoor resting mosquitoes were 0.12 and 0.12 respectively. The ace 1 mutation was present in higher frequency in the F1 of mosquitoes resting indoors (0.23) compared to those of mosquitoes resting outdoors (0.12). In Kimaeti, the frequencies of vgsc-L1014S and vgsc-L1014F were 0.75 and 0.05 respectively for the F1 of mosquitoes collected indoors whereas those of outdoor resting ones were 0.67 and 0.03 respectively. The ace 1 G119S mutation was present in progeny of mosquitoes from Kimaeti resting indoors (0.05) whereas it was absent in those resting outdoors. Monooxygenase activity was elevated by 1.83 folds in Kisian and by 1.33 folds in Kimaeti for mosquitoes resting indoors than those resting outdoors respectively. Conclusion The study recorded high phenotypic, metabolic and genotypic insecticide resistance in indoor resting populations of malaria vectors compared to their outdoor resting counterparts. The indication of moderate resistance intensity for the indoor resting mosquitoes is alarming as it could have an operational impact on the efficacy of the existing pyrethroid based vector control tools. The use of synergist (PBO) in LLINs may be a better alternative for widespread use in these regions recording high insecticide resistance.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7920366Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2021Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC7920366Data sources: PubMed CentraleScholarship - University of CaliforniaArticle . 2021Data sources: eScholarship - University of Californiaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 United KingdomPublisher:Springer Science and Business Media LLC Funded by:WT, NIH | Maximizing combination HI..., WT | Africa Centre for Health ... +1 projectsWT ,NIH| Maximizing combination HIV prevention, uptake and retention by adolescent girls and young women ,WT| Africa Centre for Health and Population Studies: Core Support ,EC| MNSIRSESNakasone, Sarah E; Chimbindi, Natsayi; Mthiyane, Nondumiso; Nkosi, Busisiwe; Zuma, Thembelihle; Baisley, Kathy; Dreyer, Jaco; Pillay, Deenan; Floyd, Sian; Birdthistle, Isolde; Seeley, Janet; Shahmanesh, Maryam;AbstractIntroductionAdolescent girls and young women (AGYW) remain disproportionately affected by HIV. In a rural area of South Africa with an annual incidence (2011–2015) of 5 and 7% per annum for 15–19 and 20–24-year olds respectively, oral pre-exposure prophylaxis (PrEP) could provide AGYW with a form of HIV prevention they can more easily control. Using quantitative and qualitative methods, we describe findings from a study conducted in 2017 that assessed knowledge of and attitudes toward PrEP to better understand community readiness for an AGYW PrEP rollout.MethodsWe used descriptive analysis of a quantitative demographic survey (n = 8,414 ages 15–86) to identify population awareness and early PrEP adopters. We also conducted semi-structured, in-depth interviews with a purposive sample of 52 potential PrEP gatekeepers (health care workers, community leaders) to assess their potential influence in an AGYW PrEP rollout and describe the current sexual health landscape. Interviews were recorded, transcribed, and iteratively coded to identify major themes.ResultsPrEP knowledge in the general population, measured through a demographic survey, was low (n = 125/8,414, 1.49% had heard of the drug). Medicalized delivery pathways created hostility to AGYW PrEP use. Key informants had higher levels of knowledge about PrEP and saw it as a needed intervention. Community norms around adolescent sexuality, which painted sexually active youth as irresponsible and disengaged from their own health, made many ambivalent towards a PrEP rollout to AGYW. Health care workers discussed ways to shame AGYW if they tried to access PrEP as they feared the drug would encourage promiscuity and “risky” behaviour. Others interviewed opposed provision on the basis of health care equity and feared PrEP would divert both drug and human resources from treatment programs.ConclusionsThe health system in this poor, high-HIV incidence area had multiple barriers to a PrEP rollout to AGYW. Norms around adolescent sexuality and gatekeeper concerns that PrEP could divert health resources from treatment to prevention could create barriers to PrEP roll-out in this setting. Alternate modes of delivery, particularly those which are youth-led and demedicalize PrEP, must be explored.
CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7487548Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12981-020-00310-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 222visibility views 222 download downloads 18 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7487548Data sources: PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12981-020-00310-2&type=result"></script>'); --> </script>
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